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USP18 ubiquitin specific peptidase 18 [ Homo sapiens (human) ]

Gene ID: 11274, updated on 13-Mar-2020

Summary

Official Symbol
USP18provided by HGNC
Official Full Name
ubiquitin specific peptidase 18provided by HGNC
Primary source
HGNC:HGNC:12616
See related
Ensembl:ENSG00000184979 MIM:607057
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ISG43; UBP43; PTORCH2
Summary
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in fat (RPKM 6.5), spleen (RPKM 6.3) and 25 other tissues See more
Orthologs

Genomic context

See USP18 in Genome Data Viewer
Location:
22q11.21
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (18149855..18177397)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (18632758..18660164)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 26 Neighboring gene ADP ribosylation factor like GTPase 2 binding protein pseudogene 10 Neighboring gene tubulin alpha 8 Neighboring gene family with sequence similarity 230 member D Neighboring gene uncharacterized LOC105372858

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 and the viral protein Tat modulate the expression of ubiquitin specific peptidase 18 (USP18; ISG43) in immature dendritic cells and monocyte-derived macrophages PubMed
Vpr vpr HIV-1 Vpr upregulates the gene expression of USP18 in human monocyte-derived dendritic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitinyl hydrolase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of type I interferon-mediated signaling pathway TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ubl carboxyl-terminal hydrolase 18
Names
43 kDa ISG15-specific protease
ISG15-specific-processing protease
hUBP43
ubiquitin specific protease 18
ubl thioesterase 18
ubl thiolesterase 18
NP_059110.2
XP_006724137.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017414.4NP_059110.2  ubl carboxyl-terminal hydrolase 18

    See identical proteins and their annotated locations for NP_059110.2

    Status: VALIDATED

    Source sequence(s)
    AC008079
    Consensus CDS
    CCDS13752.1
    UniProtKB/Swiss-Prot
    Q9UMW8
    Related
    ENSP00000215794.7, ENST00000215794.8
    Conserved Domains (1) summary
    pfam00443
    Location:55367
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    18149855..18177397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724074.3XP_006724137.1  ubl carboxyl-terminal hydrolase 18 isoform X1

    Conserved Domains (2) summary
    cd02257
    Location:60294
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:4293
    UCH; Ubiquitin carboxyl-terminal hydrolase
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