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PRR4 proline rich 4 [ Homo sapiens (human) ]

Gene ID: 11272, updated on 4-Jul-2021

Summary

Official Symbol
PRR4provided by HGNC
Official Full Name
proline rich 4provided by HGNC
Primary source
HGNC:HGNC:18020
See related
Ensembl:ENSG00000111215 MIM:605359
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPRP; PROL4
Summary
This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. [provided by RefSeq, Feb 2011]
Expression
Restricted expression toward salivary gland (RPKM 1815.0) See more
Orthologs
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Genomic context

See PRR4 in Genome Data Viewer
Location:
12p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (10845849..10849475, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10998448..11002074, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984459 Neighboring gene taste 2 receptor member 7 pseudogene Neighboring gene taste 2 receptor member 10 Neighboring gene PRH1-PRR4 readthrough Neighboring gene Sharpr-MPRA regulatory region 13514 Neighboring gene taste 2 receptor member 12 pseudogene Neighboring gene proline rich protein HaeIII subfamily 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough PRH1-PRR4

Readthrough gene: PRH1-PRR4, Included gene: PRH1

Homology

Clone Names

  • FLJ18757, DKFZp779L1763

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 

General protein information

Preferred Names
proline-rich protein 4
Names
lacrimal proline-rich protein
nasopharyngeal carcinoma-associated proline-rich protein 4
proline rich 4 (lacrimal)
proline-rich polypeptide 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098538.3NP_001092008.2  proline-rich protein 4 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 2. The resulting isoform (1) has a distinct and shorter C-terminus, compared to isoform 2.
    Source sequence(s)
    AF530472, AK292934, BX537839
    Consensus CDS
    CCDS55804.1
    UniProtKB/Swiss-Prot
    Q16378
    Related
    ENSP00000438046.1, ENST00000544994.5
  2. NM_007244.3NP_009175.2  proline-rich protein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_009175.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AF530472, DB229285
    Consensus CDS
    CCDS41756.1
    UniProtKB/Swiss-Prot
    Q16378
    Related
    ENSP00000228811.4, ENST00000228811.8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    10845849..10849475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003571050.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    44555..48181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187658.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    44555..48181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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