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XPOT exportin for tRNA [ Homo sapiens (human) ]

Gene ID: 11260, updated on 9-Feb-2020

Summary

Official Symbol
XPOTprovided by HGNC
Official Full Name
exportin for tRNAprovided by HGNC
Primary source
HGNC:HGNC:12826
See related
Ensembl:ENSG00000184575 MIM:603180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XPO3
Summary
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 36.4), brain (RPKM 13.8) and 25 other tissues See more
Orthologs

Genomic context

See XPOT in Genome Data Viewer
Location:
12q14.2
Exon count:
26
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (64404392..64451125)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (64798153..64842464)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene chromosome 12 open reading frame 56 Neighboring gene ATPase H+ transporting V1 subunit E1 pseudogene 3 Neighboring gene ribosomal protein S11 pseudogene 6 Neighboring gene mitochondrial ribosomal protein S25 pseudogene Neighboring gene TANK binding kinase 1 Neighboring gene uncharacterized LOC105369803

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Exportin-t-mediated nuclear-cytoplasmic transport of the eEF1A/Nef complexes in monocyte-derived macrophages is invloved in the inhibition of apoptosis triggered by stress PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ran GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
tRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
tRNA export from nucleus TAS
Traceable Author Statement
more info
 
tRNA re-export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nuclear matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
exportin-T
Names
exportin(tRNA)
exportin, tRNA (nuclear export receptor for tRNAs)
tRNA exportin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007235.6NP_009166.2  exportin-T

    See identical proteins and their annotated locations for NP_009166.2

    Status: REVIEWED

    Source sequence(s)
    AC135279, AK292884, BC020569, CR979468
    Consensus CDS
    CCDS31852.1
    UniProtKB/Swiss-Prot
    O43592
    Related
    ENSP00000327821.5, ENST00000332707.10
    Conserved Domains (2) summary
    smart00913
    Location:2188
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:100247
    Xpo1; Exportin 1-like protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    64404392..64451125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018748.1XP_016874237.1  exportin-T isoform X1

    UniProtKB/Swiss-Prot
    O43592
    Conserved Domains (2) summary
    smart00913
    Location:2188
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:100247
    Xpo1; Exportin 1-like protein

RNA

  1. XR_944484.3 RNA Sequence

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