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DCTN3 dynactin subunit 3 [ Homo sapiens (human) ]

Gene ID: 11258, updated on 7-Jun-2020

Summary

Official Symbol
DCTN3provided by HGNC
Official Full Name
dynactin subunit 3provided by HGNC
Primary source
HGNC:HGNC:2713
See related
Ensembl:ENSG00000137100 MIM:607387
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCTN22; DCTN-22
Summary
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in brain (RPKM 30.6), bone marrow (RPKM 26.1) and 25 other tissues See more
Orthologs

Genomic context

See DCTN3 in Genome Data Viewer
Location:
9p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (34613545..34620523, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34613542..34620520, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ciliary neurotrophic factor receptor Neighboring gene uncharacterized LOC105376023 Neighboring gene CNTFR antisense RNA 1 Neighboring gene ribonuclease P/MRP subunit p25 like Neighboring gene AT-rich interaction domain 3C Neighboring gene sigma non-opioid intracellular receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111190

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton-dependent cytokinesis IDA
Inferred from Direct Assay
more info
PubMed 
microtubule-based process IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynactin complex IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
midbody IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynactin subunit 3
Names
dynactin 3 (p22)
dynactin complex subunit 22 kDa subunit
dynactin light chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281425.1NP_001268354.1  dynactin subunit 3 isoform 3

    See identical proteins and their annotated locations for NP_001268354.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    BI837796, CN257020, DA212054
    Consensus CDS
    CCDS65028.1
    UniProtKB/Swiss-Prot
    O75935
    Related
    ENSP00000368196.4, ENST00000378916.8
    Conserved Domains (1) summary
    pfam07426
    Location:10142
    Dynactin_p22; Dynactin subunit p22
  2. NM_001281426.2NP_001268355.1  dynactin subunit 3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a translational frameshift, compared to variant 1. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC107697, BI596981, CN257020, DA212054
    UniProtKB/Swiss-Prot
    O75935
    Related
    ENSP00000368193.2, ENST00000378913.6
    Conserved Domains (1) summary
    pfam07426
    Location:10137
    Dynactin_p22; Dynactin subunit p22
  3. NM_001281427.2NP_001268356.1  dynactin subunit 3 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (5) is shorter and contains a distinct internal segment, compared to isoform 1.
    Source sequence(s)
    AW953496, CN257020, DA212054
    Consensus CDS
    CCDS65029.1
    UniProtKB/TrEMBL
    X6RLR1
    Related
    ENSP00000432915.2, ENST00000477738.6
    Conserved Domains (1) summary
    pfam07426
    Location:10160
    Dynactin_p22; Dynactin subunit p22
  4. NM_007234.5NP_009165.1  dynactin subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_009165.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC107697, CN257020, DA212054
    Consensus CDS
    CCDS6560.1
    UniProtKB/Swiss-Prot
    O75935
    Related
    ENSP00000259632.7, ENST00000259632.12
    Conserved Domains (1) summary
    pfam07426
    Location:10170
    Dynactin_p22; Dynactin subunit p22
  5. NM_024348.4NP_077324.1  dynactin subunit 3 isoform 2

    See identical proteins and their annotated locations for NP_077324.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a translational frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC000319, CN257020, DA212054
    Consensus CDS
    CCDS6561.1
    UniProtKB/Swiss-Prot
    O75935
    Related
    ENSP00000343986.2, ENST00000341694.6
    Conserved Domains (1) summary
    pfam07426
    Location:10155
    Dynactin_p22; Dynactin subunit p22

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    34613545..34620523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002956748.1 RNA Sequence

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