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SNX18 sorting nexin 18 [ Homo sapiens (human) ]

Gene ID: 112574, updated on 17-Jun-2019

Summary

Official Symbol
SNX18provided by HGNC
Official Full Name
sorting nexin 18provided by HGNC
Primary source
HGNC:HGNC:19245
See related
Ensembl:ENSG00000178996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNAG1; SH3PX2; SH3PXD3B
Summary
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 13.6), ovary (RPKM 10.4) and 25 other tissues See more
Orthologs

Genomic context

See SNX18 in Genome Data Viewer
Location:
5q11.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (54517759..54619249)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (53813589..53842416)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1033 Neighboring gene ribosomal protein L37 pseudogene 25 Neighboring gene heat shock protein family B (small) member 3 Neighboring gene uncharacterized LOC105378967 Neighboring gene uncharacterized LOC105378968 Neighboring gene uncharacterized LOC102467080 Neighboring gene uncharacterized LOC105378969

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Viral bimolecular fluorescence complementation assay demonstrates the association of HIV-1 Nef with SNX18 in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
    Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11997, FLJ32560, FLJ61062, MGC150827, MGC150829

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cleavage furrow formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosomal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sorting nexin-18
Names
SH3 and PX domain-containing protein 3B
sorting nexin associated golgi protein 1
sorting nexin-associated Golgi protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102575.2NP_001096045.1  sorting nexin-18 isoform a

    See identical proteins and their annotated locations for NP_001096045.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (a).
    Source sequence(s)
    AC091888, AI335241, AI669182, AK022059, BC060791, BJ990551, CD722181
    Consensus CDS
    CCDS43317.1
    UniProtKB/Swiss-Prot
    Q96RF0
    Related
    ENSP00000370817.4, ENST00000381410.5
    Conserved Domains (3) summary
    cd07286
    Location:276403
    PX_SNX18; The phosphoinositide binding Phox Homology domain of Sorting Nexin 18
    cd07670
    Location:415621
    BAR_SNX18; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 18
    cd11897
    Location:458
    SH3_SNX18; Src Homology 3 domain of Sorting nexin 18
  2. NM_001145427.2NP_001138899.1  sorting nexin-18 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate donor splice site at the first coding exon compared to transcript variant 1. This results in a frame-shift, early translation termination, and an isoform (c) with a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC091888, AI335241, AK022059, AK304195, BC060791, BC117220, BJ990552, CN360136
    Consensus CDS
    CCDS54851.1
    UniProtKB/Swiss-Prot
    Q96RF0
    Related
    ENSP00000317332.4, ENST00000326277.5
    Conserved Domains (3) summary
    cd07286
    Location:276403
    PX_SNX18; The phosphoinositide binding Phox Homology domain of Sorting Nexin 18
    cd11897
    Location:458
    SH3_SNX18; Src Homology 3 domain of Sorting nexin 18
    cl12013
    Location:415541
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. NM_052870.3NP_443102.2  sorting nexin-18 isoform b

    See identical proteins and their annotated locations for NP_443102.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region compared to variant 1. The resulting protein (isoform b) has a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC091888, AF395536, BC060791, BC117220, CN479485
    Consensus CDS
    CCDS3962.1
    UniProtKB/Swiss-Prot
    Q96RF0
    Related
    ENSP00000342276.7, ENST00000343017.11
    Conserved Domains (3) summary
    cd07286
    Location:276403
    PX_SNX18; The phosphoinositide binding Phox Homology domain of Sorting Nexin 18
    cd11897
    Location:458
    SH3_SNX18; Src Homology 3 domain of Sorting nexin 18
    cl12013
    Location:415541
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    54517759..54619249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008997.1XP_016864486.1  sorting nexin-18 isoform X1

    Conserved Domains (3) summary
    cd07286
    Location:276403
    PX_SNX18; The phosphoinositide binding Phox Homology domain of Sorting Nexin 18
    cd11897
    Location:458
    SH3_SNX18; Src Homology 3 domain of Sorting nexin 18
    cl12013
    Location:415541
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_001741987.1 RNA Sequence

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