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GPR45 G protein-coupled receptor 45 [ Homo sapiens (human) ]

Gene ID: 11250, updated on 24-Nov-2020

Summary

Official Symbol
GPR45provided by HGNC
Official Full Name
G protein-coupled receptor 45provided by HGNC
Primary source
HGNC:HGNC:4503
See related
Ensembl:ENSG00000135973 MIM:604838
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSP24; PSP24A; PSP24(ALPHA)
Summary
This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See GPR45 in Genome Data Viewer
Location:
2q12.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (105241743..105243467)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (105839595..105860085)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1918 Neighboring gene uncharacterized LOC105373528 Neighboring gene transforming growth factor beta receptor associated protein 1 Neighboring gene C2orf49 divergent transcript Neighboring gene chromosome 2 open reading frame 49

Genomic regions, transcripts, and products

Phenotypes

Associated conditions

Description Tests
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 45
Names
PSP24-1
PSP24-alpha
high-affinity lysophosphatidic acid receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007227.3NP_009158.3  probable G-protein coupled receptor 45

    See identical proteins and their annotated locations for NP_009158.3

    Status: REVIEWED

    Source sequence(s)
    AC012360, BC066880
    Consensus CDS
    CCDS2066.1
    UniProtKB/Swiss-Prot
    Q9Y5Y3
    UniProtKB/TrEMBL
    B5B0C1
    Related
    ENSP00000258456.1, ENST00000258456.3
    Conserved Domains (1) summary
    cd15403
    Location:35335
    7tmA_GPR45; G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    105241743..105243467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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