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GTF3C6 general transcription factor IIIC subunit 6 [ Homo sapiens (human) ]

Gene ID: 112495, updated on 21-Dec-2019

Summary

Official Symbol
GTF3C6provided by HGNC
Official Full Name
general transcription factor IIIC subunit 6provided by HGNC
Primary source
HGNC:HGNC:20872
See related
Ensembl:ENSG00000155115 MIM:611784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6orf51; TFIIIC35; bA397G5.3
Summary
RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in prostate (RPKM 34.5), testis (RPKM 28.5) and 25 other tissues See more
Orthologs

Genomic context

See GTF3C6 in Genome Data Viewer
Location:
6q21
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (110958706..110967872)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (111279763..111289091)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene adenosylmethionine decarboxylase 1 Neighboring gene calponin 2 pseudogene 9 Neighboring gene PDGFA associated protein 1 pseudogene Neighboring gene ribosome production factor 2 homolog Neighboring gene RNA, U6 small nuclear 906, pseudogene Neighboring gene glutathione S-transferase mu 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
general transcription factor 3C polypeptide 6
Names
TFIIIC 35 kDa subunit
general transcription factor IIIC, polypeptide 6, alpha 35kDa
transcription factor IIIC 35 kDa subunit
transcription factor IIIC 35kDa
transcription factor IIIC subunit 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138408.4NP_612417.1  general transcription factor 3C polypeptide 6

    See identical proteins and their annotated locations for NP_612417.1

    Status: VALIDATED

    Source sequence(s)
    AF361496
    Consensus CDS
    CCDS5087.1
    UniProtKB/Swiss-Prot
    Q969F1
    Related
    ENSP00000357863.4, ENST00000329970.8
    Conserved Domains (1) summary
    pfam10419
    Location:4376
    TFIIIC_sub6; TFIIIC subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    110958706..110967872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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