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NXPH4 neurexophilin 4 [ Homo sapiens (human) ]

Gene ID: 11247, updated on 5-Aug-2022

Summary

Official Symbol
NXPH4provided by HGNC
Official Full Name
neurexophilin 4provided by HGNC
Primary source
HGNC:HGNC:8078
See related
Ensembl:ENSG00000182379 MIM:604637; AllianceGenome:HGNC:8078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPH4
Summary
Predicted to enable signaling receptor binding activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 4.7), brain (RPKM 3.2) and 13 other tissues See more
Orthologs
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Genomic context

See NXPH4 in Genome Data Viewer
Location:
12q13.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (57216794..57226449)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (57185042..57194687)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57610577..57620232)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein 1 Neighboring gene Sharpr-MPRA regulatory region 9665 Neighboring gene microRNA 1228 Neighboring gene Sharpr-MPRA regulatory region 225 Neighboring gene serine hydroxymethyltransferase 2 Neighboring gene NDUFA4 mitochondrial complex associated like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in neuropeptide signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neurexophilin-4
Names
alternative protein NXPH4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007224.4NP_009155.1  neurexophilin-4 precursor

    See identical proteins and their annotated locations for NP_009155.1

    Status: VALIDATED

    Source sequence(s)
    AC137834
    Consensus CDS
    CCDS8933.1
    UniProtKB/Swiss-Prot
    O95158, Q8N462
    Related
    ENSP00000333593.6, ENST00000349394.6
    Conserved Domains (1) summary
    pfam06312
    Location:90307
    Neurexophilin; Neurexophilin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    57216794..57226449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018747.2XP_016874236.1  neurexophilin-4 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    57185042..57194687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)