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SHLD3 shieldin complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 112441434, updated on 26-Oct-2022

Summary

Official Symbol
SHLD3provided by HGNC
Official Full Name
shieldin complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:53826
See related
Ensembl:ENSG00000253251 MIM:618030; AllianceGenome:HGNC:53826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RINN1; CTC-534A2.2
Summary
Involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Located in site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See SHLD3 in Genome Data Viewer
Location:
5q12.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (65625027..65630928)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (66446811..66452696)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (64920854..64926755)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene tripartite motif containing 23 Neighboring gene RNA, U6 small nuclear 540, pseudogene Neighboring gene trafficking protein particle complex subunit 13 Neighboring gene small glutamine rich tetratricopeptide repeat co-chaperone beta Neighboring gene PRAME family member 17 pseudogene Neighboring gene neurolysin

Genomic regions, transcripts, and products

General gene information

Homology

Clone Names

  • AC008560.1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IC
Inferred by Curator
more info
PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of double-strand break IC
Inferred by Curator
more info
PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
shieldin complex subunit 3
Names
REV7-interacting novel NHEJ regulator 1
shield complex subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365341.2NP_001352270.1  shieldin complex subunit 3

    Status: VALIDATED

    Source sequence(s)
    AC008560
    Consensus CDS
    CCDS93722.1
    UniProtKB/Swiss-Prot
    Q6ZNX1
    Related
    ENSP00000424007.2, ENST00000510585.3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    65625027..65630928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    66446811..66452696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)