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Dxo decapping exoribonuclease [ Mus musculus (house mouse) ]

Gene ID: 112403, updated on 18-Feb-2023

Summary

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Official Symbol
Dxoprovided by MGI
Official Full Name
decapping exoribonucleaseprovided by MGI
Primary source
MGI:MGI:1890444
See related
Ensembl:ENSMUSG00000040482 AllianceGenome:MGI:1890444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NG6; Dom3z
Summary
Enables several functions, including 5'-3' exonuclease activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; and magnesium ion binding activity. Involved in RNA destabilization and nucleic acid metabolic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Orthologous to human DXO (decapping exoribonuclease). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 25.8), duodenum adult (RPKM 18.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dxo in Genome Data Viewer
Location:
17; 17 B1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35055972..35058162)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34836996..34839187)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene complement component 4A (Rodgers blood group) Neighboring gene C4a promoter region Neighboring gene C4a androgen-responsive enhancer Neighboring gene serine/threonine kinase 19 Neighboring gene SKI2 subunit of superkiller complex Neighboring gene microRNA 6971 Neighboring gene microRNA 6970

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs. Doamekpor SK, et al. Nucleic Acids Res, 2020 Jun 19. PMID 32374864, Free PMC Article
  2. Molecular mechanism for the inhibition of DXO by adenosine 3',5'-bisphosphate. Yun JS, et al. Biochem Biophys Res Commun, 2018 Sep 26. PMID 30180947, Free PMC Article
  3. 5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding. Jiao X, et al. Cell, 2017 Mar 9. PMID 28283058, Free PMC Article
  4. A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Jiao X, et al. Mol Cell, 2013 Apr 11. PMID 23523372, Free PMC Article
  5. A novel 5'-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes. Doamekpor SK, et al. Nucleic Acids Res, 2020 Jan 10. PMID 31777937, Free PMC Article

See all (15) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs.
    Title: DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs.
  2. A novel 5'-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes has been reported.
    Title: A novel 5'-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes.
  3. Report Dom3Z has role in pre-mRNA 5' end capping quality control mechanism and suggest link between proper 5' end capping and subsequent pre-mRNA processing.
    Title: A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-3' exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA NAD-cap (NAD-forming) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 5'-diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables mRNA 5'-diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD-cap decapping IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in NAD-cap decapping IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NAD-cap decapping ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear mRNA surveillance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in nucleic acid phosphodiester bond hydrolysis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in nucleic acid phosphodiester bond hydrolysis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
decapping and exoribonuclease protein
Names
5'-3' exoribonuclease DXO
NAD-capped RNA hydrolase DXO
deNADding enzyme DXO
protein Dom3Z
NP_001157242.1
NP_291091.2
XP_011244553.1
XP_017172700.1
XP_036016158.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163770.2 → NP_001157242.1  decapping and exoribonuclease protein isoform 1

    See identical proteins and their annotated locations for NP_001157242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    CT573030
    Consensus CDS
    CCDS28660.1
    UniProtKB/Swiss-Prot
    O70348
    UniProtKB/TrEMBL
    A0A0R4J288
    Related
    ENSMUSP00000137234.2, ENSMUST00000180043.8
    Conserved Domains (1) summary
    pfam08652
    Location:235 → 302
    RAI1; RAI1 like PD-(D/E)XK nuclease

  2. NM_001413617.1 → NP_001400546.1  decapping and exoribonuclease protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT573030

  3. NM_001413618.1 → NP_001400547.1  decapping and exoribonuclease protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT573030

  4. NM_033613.3 → NP_291091.2  decapping and exoribonuclease protein isoform 1

    See identical proteins and their annotated locations for NP_291091.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    CT573030
    Consensus CDS
    CCDS28660.1
    UniProtKB/Swiss-Prot
    O70348
    UniProtKB/TrEMBL
    A0A0R4J288
    Related
    ENSMUSP00000047018.9, ENSMUST00000046244.15
    Conserved Domains (1) summary
    pfam08652
    Location:235 → 302
    RAI1; RAI1 like PD-(D/E)XK nuclease

RNA

  1. NR_182175.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT573030

  2. NR_182176.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT573030

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35055972..35058162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317211.3 → XP_017172700.1  decapping and exoribonuclease protein isoform X1

    Conserved Domains (1) summary
    pfam08652
    Location:185 → 250
    RAI1; RAI1 like PD-(D/E)XK nuclease

  2. XM_011246251.4 → XP_011244553.1  decapping and exoribonuclease protein isoform X2

    See identical proteins and their annotated locations for XP_011244553.1

    Related
    ENSMUSP00000134332.2, ENSMUST00000173874.8
    Conserved Domains (1) summary
    pfam08652
    Location:235 → 300
    RAI1; RAI1 like PD-(D/E)XK nuclease

  3. XM_036160265.1 → XP_036016158.1  decapping and exoribonuclease protein isoform X1

    Conserved Domains (1) summary
    pfam08652
    Location:185 → 250
    RAI1; RAI1 like PD-(D/E)XK nuclease

RNA

  1. XR_003952077.1 RNA Sequence

  2. XR_385263.5 RNA Sequence

  3. XR_004939460.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70348.2 GenPept UniProtKB/Swiss-Prot:O70348

Gene LinkOut

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