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RNF24 ring finger protein 24 [ Homo sapiens (human) ]

Gene ID: 11237, updated on 7-Jun-2020

Summary

Official Symbol
RNF24provided by HGNC
Official Full Name
ring finger protein 24provided by HGNC
Primary source
HGNC:HGNC:13779
See related
Ensembl:ENSG00000101236 MIM:612489
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G1L
Summary
This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 12.4), brain (RPKM 5.0) and 23 other tissues See more
Orthologs

Genomic context

See RNF24 in Genome Data Viewer
Location:
20p13
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (3927311..4015588, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3912068..3996216, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene PANK2 antisense RNA 1 Neighboring gene pantothenate kinase 2 Neighboring gene microRNA 103a-2 Neighboring gene microRNA 103b-2 Neighboring gene ferritin light chain pseudogene 3 Neighboring gene ribosomal protein L21 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134337.3NP_001127809.1  RING finger protein 24 isoform 1

    See identical proteins and their annotated locations for NP_001127809.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AL031670, BC039584, BQ181223, CD367454, HY140488
    Consensus CDS
    CCDS13074.1
    UniProtKB/Swiss-Prot
    Q9Y225
    Related
    ENSP00000351166.6, ENST00000358395.11
    Conserved Domains (1) summary
    cd16469
    Location:76122
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins
  2. NM_001134338.3NP_001127810.1  RING finger protein 24 isoform 2

    See identical proteins and their annotated locations for NP_001127810.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a different segment for its 5' UTR and includes an alternate segment which uses an upstream AUG codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AL031670, BC000213, BQ181223, CD367454, HY140488
    Consensus CDS
    CCDS46577.1
    UniProtKB/Swiss-Prot
    Q9Y225
    Related
    ENSP00000444711.1, ENST00000545616.2
    Conserved Domains (1) summary
    cd16469
    Location:97143
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins
  3. NM_001321749.2NP_001308678.1  RING finger protein 24 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AL031670, BQ181223, HY050527, HY140488
    Consensus CDS
    CCDS13074.1
    UniProtKB/Swiss-Prot
    Q9Y225
    Conserved Domains (1) summary
    cd16469
    Location:76122
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins
  4. NM_007219.5NP_009150.1  RING finger protein 24 isoform 1

    See identical proteins and their annotated locations for NP_009150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript yet it encodes the shorter isoform (1). Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AL031670, AL096778, BQ181223, CD367454, HY050527, HY140488
    Consensus CDS
    CCDS13074.1
    UniProtKB/Swiss-Prot
    Q9Y225
    Related
    ENSP00000336753.5, ENST00000336095.10
    Conserved Domains (1) summary
    cd16469
    Location:76122
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    3927311..4015588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529145.3XP_011527447.1  RING finger protein 24 isoform X1

    See identical proteins and their annotated locations for XP_011527447.1

    UniProtKB/Swiss-Prot
    Q9Y225
    Conserved Domains (1) summary
    cd16469
    Location:97143
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins
  2. XM_017027620.1XP_016883109.1  RING finger protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y225
    Conserved Domains (1) summary
    cd16469
    Location:97143
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins
  3. XM_011529146.2XP_011527448.1  RING finger protein 24 isoform X2

    Conserved Domains (1) summary
    cd16469
    Location:91137
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins
  4. XM_017027621.1XP_016883110.1  RING finger protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y225
    Related
    ENSP00000388550.2, ENST00000432261.6
    Conserved Domains (1) summary
    cd16469
    Location:97143
    RING-H2_RNF24_like; RING finger, H2 subclass, found in RING finger proteins RNF24, RNF122, and similar proteins
  5. XM_017027622.2XP_016883111.1  RING finger protein 24 isoform X3

    Conserved Domains (1) summary
    pfam17123
    Location:99124
    zf-RING_11; RING-like zinc finger
  6. XM_011529147.2XP_011527449.1  RING finger protein 24 isoform X3

    Conserved Domains (1) summary
    pfam17123
    Location:99124
    zf-RING_11; RING-like zinc finger
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