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PRAF2 PRA1 domain family member 2 [ Homo sapiens (human) ]

Gene ID: 11230, updated on 22-Sep-2022

Summary

Official Symbol
PRAF2provided by HGNC
Official Full Name
PRA1 domain family member 2provided by HGNC
Primary source
HGNC:HGNC:28911
See related
Ensembl:ENSG00000243279 MIM:300840; AllianceGenome:HGNC:28911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JM4; Yip6a
Summary
Predicted to be involved in L-glutamate transmembrane transport. Predicted to be located in endosome membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 27.2), testis (RPKM 14.5) and 24 other tissues See more
Orthologs
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Genomic context

See PRAF2 in Genome Data Viewer
Location:
Xp11.23
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (49071161..49074002, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (48482886..48485729, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48928818..48931661, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-FlowFISH-validated PQBP1 regulatory element Neighboring gene Sharpr-MPRA regulatory region 13918 Neighboring gene coiled-coil domain containing 120 Neighboring gene WD repeat domain 45 Neighboring gene Sharpr-MPRA regulatory region 1999 Neighboring gene RNA, U4 small nuclear 52, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with PRAF2; predicted interaction to be within the endoplasmic reticulum to Golgi transport PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: WDR45

Homology

Clone Names

  • FLJ57916

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in L-glutamate transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
PRA1 family protein 2
Names
Jena-Muenchen 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007213.3NP_009144.1  PRA1 family protein 2

    See identical proteins and their annotated locations for NP_009144.1

    Status: VALIDATED

    Source sequence(s)
    AC231657, AJ005896
    Consensus CDS
    CCDS14317.1
    UniProtKB/Swiss-Prot
    B2RD20, O60831
    UniProtKB/TrEMBL
    A0A024QZ22
    Related
    ENSP00000451962.2, ENST00000553851.3
    Conserved Domains (1) summary
    pfam03208
    Location:4149
    PRA1; PRA1 family protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    49071161..49074002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791820.1 Reference GRCh38.p14 PATCHES

    Range
    230112..232953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    48482886..48485729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)