Format

Send to:

Choose Destination

GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 [ Homo sapiens (human) ]

Gene ID: 11227, updated on 11-Sep-2019

Summary

Official Symbol
GALNT5provided by HGNC
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 5provided by HGNC
Primary source
HGNC:HGNC:4127
See related
Ensembl:ENSG00000136542 MIM:615129
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GALNACT5; GALNAC-T5
Summary
The protein encoded by this gene is a membrane-bound polypeptide N-acetylgalactosaminyltransferase that is found in the Golgi. The encoded protein catalyzes the first step in the mucin-type O-glycosylation of Golgi proteins, transfering an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. [provided by RefSeq, Aug 2016]
Expression
Biased expression in colon (RPKM 10.1), lung (RPKM 7.0) and 7 other tissues See more
Orthologs

Genomic context

See GALNT5 in Genome Data Viewer
Location:
2q24.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (157257656..157318491)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (158114340..158167913)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373710 Neighboring gene uncharacterized LOC105373709 Neighboring gene VISTA enhancer hs415 Neighboring gene cyclin dependent kinase 7 pseudogene 1 Neighboring gene RN7SK pseudogene 281 Neighboring gene ermin Neighboring gene family with sequence similarity 133, member A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC165041

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
O-glycan processing TAS
Traceable Author Statement
more info
 
glycosaminoglycan biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
cellular_component ND
No biological Data available
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
polypeptide N-acetylgalactosaminyltransferase 5
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
polypeptide GalNAc transferase 5
pp-GaNTase 5
protein-UDP acetylgalactosaminyltransferase 5
NP_001316797.1
NP_055383.1
XP_016858726.1
XP_016858727.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329868.2NP_001316797.1  polypeptide N-acetylgalactosaminyltransferase 5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC016732, AY277591, BC142676, BC144211, BX117716
    UniProtKB/Swiss-Prot
    Q7Z7M9
  2. NM_014568.3NP_055383.1  polypeptide N-acetylgalactosaminyltransferase 5 isoform 1

    See identical proteins and their annotated locations for NP_055383.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC016732, AY277591, BC142676, BX117716
    Consensus CDS
    CCDS2203.1
    UniProtKB/Swiss-Prot
    Q7Z7M9
    Related
    ENSP00000259056.4, ENST00000259056.5
    Conserved Domains (4) summary
    cd02510
    Location:499800
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:494609
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:812934
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:810932
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    157257656..157318491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003237.2XP_016858726.1  polypeptide N-acetylgalactosaminyltransferase 5 isoform X1

  2. XM_017003238.2XP_016858727.1  polypeptide N-acetylgalactosaminyltransferase 5 isoform X2

Support Center