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GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 11226, updated on 13-Mar-2020

Summary

Official Symbol
GALNT6provided by HGNC
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 6provided by HGNC
Primary source
HGNC:HGNC:4128
See related
Ensembl:ENSG00000139629 MIM:605148
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GalNAcT6; GALNAC-T6
Summary
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]
Expression
Broad expression in stomach (RPKM 18.9), small intestine (RPKM 7.1) and 16 other tissues See more
Orthologs

Genomic context

See GALNT6 in Genome Data Viewer
Location:
12q13.13
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (51351252..51391955, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51745654..51785739, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene bridging integrator 2 Neighboring gene uncharacterized LOC105369767 Neighboring gene chymotrypsin like elastase 1 Neighboring gene solute carrier family 4 member 8 Neighboring gene uncharacterized LOC107984508 Neighboring gene uncharacterized LOC105369768

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
polypeptide N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
O-glycan processing TAS
Traceable Author Statement
more info
 
protein O-linked glycosylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polypeptide N-acetylgalactosaminyltransferase 6
Names
GalNAc transferase 6
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
polypeptide GalNAc transferase 6
pp-GaNTase 6
protein-UDP acetylgalactosaminyltransferase 6
NP_009141.2
XP_005268664.1
XP_006719277.1
XP_011536121.1
XP_011536124.1
XP_016874234.1
XP_024304579.1
XP_024304580.1
XP_024304581.1
XP_024304582.1
XP_024304583.1
XP_024304584.1
XP_024304585.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007210.4NP_009141.2  polypeptide N-acetylgalactosaminyltransferase 6

    See identical proteins and their annotated locations for NP_009141.2

    Status: REVIEWED

    Source sequence(s)
    AC046135, BC035822, DB001644
    Consensus CDS
    CCDS8813.1
    UniProtKB/Swiss-Prot
    Q8NCL4
    Related
    ENSP00000348668.2, ENST00000356317.8
    Conserved Domains (2) summary
    cd02510
    Location:180485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    51351252..51391955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268607.1XP_005268664.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    See identical proteins and their annotated locations for XP_005268664.1

    UniProtKB/Swiss-Prot
    Q8NCL4
    Conserved Domains (2) summary
    cd02510
    Location:180485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  2. XM_024448815.1XP_024304583.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:180485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  3. XM_011537822.2XP_011536124.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    See identical proteins and their annotated locations for XP_011536124.1

    UniProtKB/Swiss-Prot
    Q8NCL4
    Conserved Domains (2) summary
    cd02510
    Location:180485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  4. XM_024448816.1XP_024304584.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:180485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  5. XM_024448811.1XP_024304579.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:180485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  6. XM_017018745.2XP_016874234.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    UniProtKB/Swiss-Prot
    Q8NCL4
    Conserved Domains (2) summary
    cd02510
    Location:180485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  7. XM_006719214.2XP_006719277.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    See identical proteins and their annotated locations for XP_006719277.1

    UniProtKB/Swiss-Prot
    Q8NCL4
    Conserved Domains (2) summary
    cd02510
    Location:180485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  8. XM_024448813.1XP_024304581.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:180485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  9. XM_024448814.1XP_024304582.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:180485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  10. XM_024448817.1XP_024304585.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:180485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  11. XM_011537819.3XP_011536121.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    See identical proteins and their annotated locations for XP_011536121.1

    UniProtKB/Swiss-Prot
    Q8NCL4
    Conserved Domains (2) summary
    cd02510
    Location:180485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
  12. XM_024448812.1XP_024304580.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:180485
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:497619
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RNA

  1. XR_001748566.2 RNA Sequence

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