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TREX2 three prime repair exonuclease 2 [ Homo sapiens (human) ]

Gene ID: 11219, updated on 2-Mar-2021

Summary

Official Symbol
TREX2provided by HGNC
Official Full Name
three prime repair exonuclease 2provided by HGNC
Primary source
HGNC:HGNC:12270
See related
Ensembl:ENSG00000183479 MIM:300370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]
Expression
Biased expression in skin (RPKM 5.9), spleen (RPKM 0.7) and 5 other tissues See more
Orthologs
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Genomic context

See TREX2 in Genome Data Viewer
Location:
Xq28
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (153444473..153446056, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (152709931..152711514, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373379 Neighboring gene PNMA family member 6E Neighboring gene RNA, 7SL, cytoplasmic 667, pseudogene Neighboring gene ZFP92 zinc finger protein Neighboring gene HAUS augmin like complex subunit 7 Neighboring gene Sharpr-MPRA regulatory region 9358 Neighboring gene extracellular matrix protein X-linked, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: HAUS7

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5'-exodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3'-5'-exodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
exodeoxyribonuclease III activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA catabolic process, exonucleolytic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
three prime repair exonuclease 2
Names
3'-5' exonuclease TREX2 long form
NP_542432.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029986.1 RefSeqGene

    Range
    5001..6768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080701.4NP_542432.2  three prime repair exonuclease 2

    See identical proteins and their annotated locations for NP_542432.2

    Status: REVIEWED

    Source sequence(s)
    U82695
    Consensus CDS
    CCDS35437.1
    UniProtKB/Swiss-Prot
    Q9BQ50
    Related
    ENSP00000359251.2, ENST00000370231.2
    Conserved Domains (1) summary
    cd06136
    Location:10204
    TREX1_2; DEDDh 3'-5' exonuclease domain of three prime repair exonuclease (TREX)1, TREX2, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    153444473..153446056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_080699.2: Suppressed sequence

    Description
    NM_080699.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  2. NM_080700.2: Suppressed sequence

    Description
    NM_080700.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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