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DDX20 DEAD-box helicase 20 [ Homo sapiens (human) ]

Gene ID: 11218, updated on 26-Nov-2021

Summary

Official Symbol
DDX20provided by HGNC
Official Full Name
DEAD-box helicase 20provided by HGNC
Primary source
HGNC:HGNC:2743
See related
Ensembl:ENSG00000064703 MIM:606168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP103; GEMIN3
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 58.2), bone marrow (RPKM 6.4) and 17 other tissues See more
Orthologs
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Genomic context

See DDX20 in Genome Data Viewer
Location:
1p13.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (111755901..111768000)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (112298523..112310622)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene RNA, U6 small nuclear 151, pseudogene Neighboring gene uncharacterized LOC101928718 Neighboring gene INKA2 antisense RNA 1 Neighboring gene inka box actin regulator 2 Neighboring gene potassium voltage-gated channel subfamily D member 3 Neighboring gene KCND3 intronic transcript 1 Neighboring gene KCND3 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 (DDX20) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434H052

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Gemini of coiled bodies IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase II transcription repressor complex IEA
Inferred from Electronic Annotation
more info
 
part_of SMN complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SMN complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SMN complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of SMN-Sm protein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX20
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DEAD box protein 20
DEAD box protein DP 103
DEAD-box protein DP103
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD
SMN-interacting protein
component of gems 3
gemin-3
NP_009135.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007204.5NP_009135.4  probable ATP-dependent RNA helicase DDX20

    See identical proteins and their annotated locations for NP_009135.4

    Status: REVIEWED

    Source sequence(s)
    AF171063, AK001506, AL049557, AY007146
    Consensus CDS
    CCDS842.1
    UniProtKB/Swiss-Prot
    Q9UHI6
    UniProtKB/TrEMBL
    Q9H4N4
    Related
    ENSP00000358716.4, ENST00000369702.5
    Conserved Domains (3) summary
    smart00487
    Location:77279
    DEXDc; DEAD-like helicases superfamily
    pfam00271
    Location:294404
    Helicase_C; Helicase conserved C-terminal domain
    cl21455
    Location:64265
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    111755901..111768000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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