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DDX20 DEAD-box helicase 20 [ Homo sapiens (human) ]

Gene ID: 11218, updated on 6-Jan-2019

Summary

Official Symbol
DDX20provided by HGNC
Official Full Name
DEAD-box helicase 20provided by HGNC
Primary source
HGNC:HGNC:2743
See related
Ensembl:ENSG00000064703 MIM:606168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP103; GEMIN3
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 58.2), bone marrow (RPKM 6.4) and 17 other tissues See more
Orthologs

Genomic context

See DDX20 in Genome Data Viewer
Location:
1p13.2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (111755568..111767577)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (112298190..112310199)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene RNA, U6 small nuclear 151, pseudogene Neighboring gene uncharacterized LOC101928718 Neighboring gene INKA2 antisense RNA 1 Neighboring gene inka box actin regulator 2 Neighboring gene potassium voltage-gated channel subfamily D member 3 Neighboring gene KCND3 intronic transcript 1 Neighboring gene KCND3 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 (DDX20) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Metabolism of non-coding RNA, organism-specific biosystem (from REACTOME)
    Metabolism of non-coding RNA, organism-specific biosystemThe term non-coding is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. There is considerable evidence tha...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Survival motor neuron (SMN) complex, organism-specific biosystem (from KEGG)
    Survival motor neuron (SMN) complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • Survival motor neuron (SMN) complex, conserved biosystem (from KEGG)
    Survival motor neuron (SMN) complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
  • snRNP Assembly, organism-specific biosystem (from REACTOME)
    snRNP Assembly, organism-specific biosystemSmall nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434H052

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent RNA helicase activity TAS
Traceable Author Statement
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA processing TAS
Traceable Author Statement
more info
PubMed 
import into nucleus TAS
Traceable Author Statement
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
oogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
spliceosomal snRNP assembly IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal snRNP assembly TAS
Traceable Author Statement
more info
 
spliceosomal tri-snRNP complex assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Gemini of coiled bodies IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription repressor complex IEA
Inferred from Electronic Annotation
more info
 
SMN complex IDA
Inferred from Direct Assay
more info
PubMed 
SMN-Sm protein complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX20
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DEAD box protein 20
DEAD box protein DP 103
DEAD-box protein DP103
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD
SMN-interacting protein
component of gems 3
gemin-3
NP_009135.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007204.5NP_009135.4  probable ATP-dependent RNA helicase DDX20

    See identical proteins and their annotated locations for NP_009135.4

    Status: REVIEWED

    Source sequence(s)
    AF171063, AK001506, AL049557, AY007146
    Consensus CDS
    CCDS842.1
    UniProtKB/Swiss-Prot
    Q9UHI6
    UniProtKB/TrEMBL
    Q9H4N4
    Related
    ENSP00000358716.4, ENST00000369702.4
    Conserved Domains (3) summary
    smart00487
    Location:77279
    DEXDc; DEAD-like helicases superfamily
    pfam00271
    Location:294404
    Helicase_C; Helicase conserved C-terminal domain
    cl21455
    Location:64265
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    111755568..111767577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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