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LOC112163662 Sharpr-MPRA regulatory region 3717 [ Homo sapiens (human) ]

Gene ID: 112163662, updated on 10-Dec-2019

Summary

Gene symbol
LOC112163662
Gene description
Sharpr-MPRA regulatory region 3717
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in HepG2 liver carcinoma cells (group: HepG2 Activating DNase matched - State 14:Gen5', transcription transition, highly expressed genes towards 5' end). It also displayed weak activation by Sharpr-MPRA in K562 erythroleukemia cells (group: K562 Activating DNase unmatched - State 17:Gen3', transcription 3' end of genes, highly expressed; more exonic). [provided by RefSeq, Mar 2018]

Genomic context

See LOC112163662 in Genome Data Viewer
Location:
13q
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (48066562..48066947)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene succinate-CoA ligase ADP-forming subunit beta Neighboring gene nudix hydrolase 15 Neighboring gene MED4 antisense RNA 1 Neighboring gene mediator complex subunit 4 Neighboring gene uncharacterized LOC105370198 Neighboring gene RNA polymerase II subunit K pseudogene 2

Genomic regions, transcripts, and products

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_056637.1 

    Range
    10..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    48066562..48066947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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