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AKAP11 A-kinase anchoring protein 11 [ Homo sapiens (human) ]

Gene ID: 11215, updated on 13-Dec-2020

Summary

Official Symbol
AKAP11provided by HGNC
Official Full Name
A-kinase anchoring protein 11provided by HGNC
Primary source
HGNC:HGNC:369
See related
Ensembl:ENSG00000023516 MIM:604696
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRKA11; AKAP-11; AKAP220; PPP1R44
Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 22.2), testis (RPKM 15.0) and 24 other tissues See more
Orthologs
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Genomic context

See AKAP11 in Genome Data Viewer
Location:
13q14.11
Exon count:
16
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (42271470..42323266)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (42846261..42897403)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr13.544 Neighboring gene CRISPRi-validated cis-regulatory element chr13.545 Neighboring gene fatty acid binding protein 3 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 2341

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
GeneReviews: Not available
Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
GeneReviews: Not available
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11304, KIAA0629, DKFZp781I12161

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase A regulatory subunit binding IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase 1 binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to endosome IEA
Inferred from Electronic Annotation
more info
 
regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 
renal water homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
A-kinase anchor protein 11
Names
A kinase (PRKA) anchor protein 11
A-kinase anchor protein 220 kDa
A-kinase anchoring protein, 220kDa
a kinase anchor protein 220 kDa
protein kinase A anchoring protein 11
protein phosphatase 1, regulatory subunit 44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016248.4NP_057332.1  A-kinase anchor protein 11

    See identical proteins and their annotated locations for NP_057332.1

    Status: REVIEWED

    Source sequence(s)
    AF176555, AL136527, BE670178, BE694434, DA780016
    Consensus CDS
    CCDS9383.1
    UniProtKB/Swiss-Prot
    Q9UKA4
    Related
    ENSP00000025301.2, ENST00000025301.4
    Conserved Domains (1) summary
    cl14906
    Location:18041900
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    42271470..42323266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534906.2XP_011533208.1  A-kinase anchor protein 11 isoform X1

    See identical proteins and their annotated locations for XP_011533208.1

    UniProtKB/Swiss-Prot
    Q9UKA4
    Conserved Domains (1) summary
    cl14906
    Location:18041900
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
  2. XM_017020383.1XP_016875872.1  A-kinase anchor protein 11 isoform X3

    Conserved Domains (1) summary
    cl14906
    Location:17591855
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
  3. XM_011534904.1XP_011533206.1  A-kinase anchor protein 11 isoform X1

    See identical proteins and their annotated locations for XP_011533206.1

    UniProtKB/Swiss-Prot
    Q9UKA4
    Conserved Domains (1) summary
    cl14906
    Location:18041900
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
  4. XM_011534903.2XP_011533205.1  A-kinase anchor protein 11 isoform X1

    See identical proteins and their annotated locations for XP_011533205.1

    UniProtKB/Swiss-Prot
    Q9UKA4
    Conserved Domains (1) summary
    cl14906
    Location:18041900
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
  5. XM_005266248.3XP_005266305.1  A-kinase anchor protein 11 isoform X3

    Conserved Domains (1) summary
    cl14906
    Location:17591855
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
  6. XM_017020382.1XP_016875871.1  A-kinase anchor protein 11 isoform X3

    Conserved Domains (1) summary
    cl14906
    Location:17591855
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
  7. XM_005266247.1XP_005266304.1  A-kinase anchor protein 11 isoform X2

    Conserved Domains (1) summary
    cl14906
    Location:16551872
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
  8. XM_011534905.1XP_011533207.1  A-kinase anchor protein 11 isoform X1

    See identical proteins and their annotated locations for XP_011533207.1

    UniProtKB/Swiss-Prot
    Q9UKA4
    Conserved Domains (1) summary
    cl14906
    Location:18041900
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
  9. XM_005266249.3XP_005266306.1  A-kinase anchor protein 11 isoform X4

  10. XM_005266250.3XP_005266307.1  A-kinase anchor protein 11 isoform X5

  11. XM_017020381.2XP_016875870.1  A-kinase anchor protein 11 isoform X1

    UniProtKB/Swiss-Prot
    Q9UKA4
    Conserved Domains (1) summary
    cl14906
    Location:18041900
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144490.1: Suppressed sequence

    Description
    NM_144490.1: This RefSeq was permanently suppressed because its 3' end is primarily intronic sequence.
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