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IRAK3 interleukin 1 receptor associated kinase 3 [ Homo sapiens (human) ]

Gene ID: 11213, updated on 3-May-2025
Official Symbol
IRAK3provided by HGNC
Official Full Name
interleukin 1 receptor associated kinase 3provided by HGNC
Primary source
HGNC:HGNC:17020
See related
Ensembl:ENSG00000090376 MIM:604459; AllianceGenome:HGNC:17020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASRT5; IRAKM
Summary
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Broad expression in bone marrow (RPKM 10.8), spleen (RPKM 8.1) and 21 other tissues See more
Orthologs
mouse all
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See IRAK3 in Genome Data Viewer
Location:
12q14.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (66189214..66254622)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (66168706..66234159)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (66582994..66648402)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6612 Neighboring gene LLPH divergent transcript Neighboring gene transmembrane BAX inhibitor motif containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6613 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:66563510-66564034 Neighboring gene MPRA-validated peak1773 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr12:66568604-66568806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4635 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:66616545-66617046 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:66617047-66617546 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6615 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4637 Neighboring gene RNA binding motif single stranded interacting protein 1 pseudogene 1 Neighboring gene microRNA 6502 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:66665559-66666184 Neighboring gene PDCL3 pseudogene 7 Neighboring gene RN7SK pseudogene 166

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Methylation of Interleukin-1 receptor-associated kinase-3 and the risk of multiple sclerosis relapse/activity. Watany MM, et al. Clin Immunol, 2024 Sep. PMID 39053866
  2. Methylation of IRAK3 is a novel prognostic marker in hepatocellular carcinoma. Kuo CC, et al. World J Gastroenterol, 2015 Apr 7. PMID 25852282, Free PMC Article
  3. The structure function of the death domain of human IRAK-M. Du J, et al. Cell Commun Signal, 2014 Dec 7. PMID 25481771, Free PMC Article
  4. Interleukin-1 receptor-associated kinase M (IRAK-M) promotes human rhinovirus infection in lung epithelial cells via the autophagic pathway. Wu Q, et al. Virology, 2013 Nov. PMID 24074582, Free PMC Article
  5. Association between gene polymorphisms of IRAK-M and the susceptibility of sepsis. Dong GH, et al. Inflammation, 2013 Oct. PMID 23588345

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Methylation of Interleukin-1 receptor-associated kinase-3 and the risk of multiple sclerosis relapse/activity.
    Title: Methylation of Interleukin-1 receptor-associated kinase-3 and the risk of multiple sclerosis relapse/activity.
  2. Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration.
    Title: Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration.
  3. Importance of serum IRAK3 as a biochemical marker in relation to severity and neurological outcome of human severe traumatic brain injury: A prospective longitudinal cohort study.
    Title: Importance of serum IRAK3 as a biochemical marker in relation to severity and neurological outcome of human severe traumatic brain injury: A prospective longitudinal cohort study.
  4. IL-1 receptor-associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy.
    Title: IL-1 receptor-associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy.
  5. Mutations in the Vicinity of the IRAK3 Guanylate Cyclase Center Impact Its Subcellular Localization and Ability to Modulate Inflammatory Signaling in Immortalized Cell Lines.
    Title: Mutations in the Vicinity of the IRAK3 Guanylate Cyclase Center Impact Its Subcellular Localization and Ability to Modulate Inflammatory Signaling in Immortalized Cell Lines.
  6. IRAK-M has effects in regulation of lung epithelial inflammation.
    Title: IRAK-M has effects in regulation of lung epithelial inflammation.
  7. Changes in plasma IRAK-M in patients with prediabetes and its relationship with related metabolic indexes: a cross-sectional study.
    Title: Changes in plasma IRAK-M in patients with prediabetes and its relationship with related metabolic indexes: a cross-sectional study.
  8. IRAK-M deletion aggravates acute inflammatory response and mitochondrial respiratory dysfunction following myocardial infarction: A bioinformatics analysis.
    Title: IRAK-M deletion aggravates acute inflammatory response and mitochondrial respiratory dysfunction following myocardial infarction: A bioinformatics analysis.
  9. Modulation of Inflammatory Cytokine Production in Human Monocytes by cGMP and IRAK3.
    Title: Modulation of Inflammatory Cytokine Production in Human Monocytes by cGMP and IRAK3.
  10. MYD88, IRAK3 and Rheumatoid Arthritis pathogenesis: Analysis of differential gene expression in CD14 + monocytes and the inflammatory cytokine levels.
    Title: MYD88, IRAK3 and Rheumatoid Arthritis pathogenesis: Analysis of differential gene expression in CD14 + monocytes and the inflammatory cytokine levels.
Submit: New GeneRIF Correction See all GeneRIFs (58)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Asthma-related traits, susceptibility to, 5
MedGen: C1970224 OMIM: 611064 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13601

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in Toll signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipopolysaccharide-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytokine-mediated signaling pathway IC
Inferred by Curator
more info
 PubMed 
involved_in negative regulation of innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of interleukin-12 production ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of interleukin-6 production ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of macrophage cytokine production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of macrophage cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein-containing complex disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of macrophage tolerance induction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of macrophage tolerance induction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein-containing complex disassembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein-containing complex disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to exogenous dsRNA IEA
Inferred from Electronic Annotation
more info
  
involved_in response to exogenous dsRNA ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to peptidoglycan IEA
Inferred from Electronic Annotation
more info
  
involved_in response to peptidoglycan ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to virus IC
Inferred by Curator
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
interleukin-1 receptor-associated kinase 3
Names
IL-1 receptor-associated kinase M
inactive IL-1 receptor-associated kinase 3
NP_001135995.1
NP_009130.2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021194.1 RefSeqGene

    Range
    5017..70425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142523.2 → NP_001135995.1  interleukin-1 receptor-associated kinase 3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC078889, AC078927, AK298645, AL049435, BP292474, BQ009433
    Consensus CDS
    CCDS44937.1
    UniProtKB/TrEMBL
    B2RA52
    Related
    ENSP00000409852.2, ENST00000457197.2
    Conserved Domains (3) summary
    smart00219
    Location:110 → 382
    TyrKc; Tyrosine kinase, catalytic domain
    cd14160
    Location:110 → 385
    PK_IRAK3; Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3
    cl14633
    Location:15 → 51
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. NM_007199.3 → NP_009130.2  interleukin-1 receptor-associated kinase 3 isoform a

    See identical proteins and their annotated locations for NP_009130.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC078889, AF113136, AL049435, BC057800, BP292474, DA594800
    Consensus CDS
    CCDS8975.1
    UniProtKB/Swiss-Prot
    B4DQ57, Q9Y616
    UniProtKB/TrEMBL
    B2RA52
    Related
    ENSP00000261233.4, ENST00000261233.9
    Conserved Domains (3) summary
    smart00219
    Location:171 → 443
    TyrKc; Tyrosine kinase, catalytic domain
    cd08796
    Location:15 → 103
    Death_IRAK-M; Death domain of Interleukin 1 Receptor Associated Kinase-M
    cd14160
    Location:171 → 446
    PK_IRAK3; Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    66189214..66254622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    66168706..66234159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y616.2 GenPept UniProtKB/Swiss-Prot:Q9Y616

Gene LinkOut

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Chemical Information
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