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FZD10 frizzled class receptor 10 [ Homo sapiens (human) ]

Gene ID: 11211, updated on 1-Aug-2020

Summary

Official Symbol
FZD10provided by HGNC
Official Full Name
frizzled class receptor 10provided by HGNC
Primary source
HGNC:HGNC:4039
See related
Ensembl:ENSG00000111432 MIM:606147
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fz10; FzE7; CD350; FZ-10; hFz10
Summary
This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See FZD10 in Genome Data Viewer
Location:
12q24.33
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (130162459..130165740)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (130647004..130650285)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2419 Neighboring gene FZD10 antisense divergent transcript Neighboring gene ribosomal protein S20 pseudogene 30 Neighboring gene uncharacterized LOC107984480

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-canonical Wnt signaling pathway via JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
frizzled-10
Names
frizzled 10, seven transmembrane spanning receptor
frizzled family receptor 10
frizzled homolog 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007197.3NP_009128.1  frizzled-10 precursor

    See identical proteins and their annotated locations for NP_009128.1

    Status: REVIEWED

    Source sequence(s)
    AB027464, AC026336, AI697875, BC070037, BC074997
    Consensus CDS
    CCDS9267.1
    UniProtKB/Swiss-Prot
    Q9ULW2
    UniProtKB/TrEMBL
    Q6NSL8
    Related
    ENSP00000229030.4, ENST00000229030.4
    Conserved Domains (2) summary
    cd07462
    Location:30156
    CRD_FZ10; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 10 (Fz10) receptor
    cd15037
    Location:217535
    7tmF_FZD10; class F frizzled subfamily 10, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    130162459..130165740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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