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WIF1 WNT inhibitory factor 1 [ Homo sapiens (human) ]

Gene ID: 11197, updated on 12-Sep-2021

Summary

Official Symbol
WIF1provided by HGNC
Official Full Name
WNT inhibitory factor 1provided by HGNC
Primary source
HGNC:HGNC:18081
See related
Ensembl:ENSG00000156076 MIM:605186
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WIF-1
Summary
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]
Expression
Biased expression in lung (RPKM 69.2), brain (RPKM 9.8) and 3 other tissues See more
Orthologs
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Genomic context

See WIF1 in Genome Data Viewer
Location:
12q14.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (65050626..65121305, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (65444406..65515085, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2389 Neighboring gene long intergenic non-protein coding RNA 2231 Neighboring gene RNA, U6atac small nuclear 42, pseudogene Neighboring gene uncharacterized LOC107984522 Neighboring gene RNA, U6 small nuclear 166, pseudogene Neighboring gene apolipoprotein O pseudogene 3 Neighboring gene LEM domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common variants at 12q14 and 12q24 are associated with hippocampal volume.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Wnt-protein binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007191.5NP_009122.2  wnt inhibitory factor 1 precursor

    See identical proteins and their annotated locations for NP_009122.2

    Status: REVIEWED

    Source sequence(s)
    AY358344, BX647427, DB560069, DC315426
    Consensus CDS
    CCDS8971.1
    UniProtKB/Swiss-Prot
    Q9Y5W5
    Related
    ENSP00000286574.4, ENST00000286574.9
    Conserved Domains (1) summary
    smart00469
    Location:35179
    WIF; Wnt-inhibitory factor-1 like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    65050626..65121305 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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