Format

Send to:

Choose Destination

WBP4 WW domain binding protein 4 [ Homo sapiens (human) ]

Gene ID: 11193, updated on 18-Aug-2021

Summary

Official Symbol
WBP4provided by HGNC
Official Full Name
WW domain binding protein 4provided by HGNC
Primary source
HGNC:HGNC:12739
See related
Ensembl:ENSG00000120688 MIM:604981
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBP21
Summary
This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 9.7), fat (RPKM 9.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See WBP4 in Genome Data Viewer
Location:
13q14.11
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (41061509..41084006)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (41635645..41658142)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene E74 like ETS transcription factor 1 Neighboring gene regulator of G protein signaling 17 pseudogene 1 Neighboring gene tRNA-Glu (anticodon TTC) 1-2 Neighboring gene microRNA 3168 Neighboring gene RNA, 7SL, cytoplasmic 597, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of WW domain binding protein 4 (formin binding protein 21, WBP4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117310

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables proline-rich region binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA cis splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
WW domain-binding protein 4
Names
WBP-4
WW domain-containing binding protein 4
domain-containing binding protein 4
formin binding protein 21

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007187.5NP_009118.1  WW domain-binding protein 4

    See identical proteins and their annotated locations for NP_009118.1

    Status: REVIEWED

    Source sequence(s)
    BC108310, BF513662, CD742574
    Consensus CDS
    CCDS9375.1
    UniProtKB/Swiss-Prot
    O75554
    Related
    ENSP00000368801.3, ENST00000379487.5
    Conserved Domains (2) summary
    COG5104
    Location:128196
    PRP40; Splicing factor [RNA processing and modification]
    pfam06220
    Location:844
    zf-U1; U1 zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    41061509..41084006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266245.2XP_005266302.1  WW domain-binding protein 4 isoform X1

    Conserved Domains (2) summary
    pfam06220
    Location:3975
    zf-U1; U1 zinc finger
    cd00201
    Location:200227
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  2. XM_017020380.1XP_016875869.1  WW domain-binding protein 4 isoform X2

    Conserved Domains (1) summary
    cd00201
    Location:1340
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
Support Center