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PTENP1 phosphatase and tensin homolog pseudogene 1 [ Homo sapiens (human) ]

Gene ID: 11191, updated on 23-Nov-2021

Summary

Official Symbol
PTENP1provided by HGNC
Official Full Name
phosphatase and tensin homolog pseudogene 1provided by HGNC
Primary source
HGNC:HGNC:9589
See related
Ensembl:ENSG00000237984 MIM:613531
Gene type
pseudo
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTH2; PTEN2; PTEN-rs; PTENpg1; psiPTEN
Summary
PTENP1 represents a highly homologous processed pseudogene of PTEN (phosphatase and tensin homolog), a protein that encodes a tumor suppressor that functions by negatively regulating the AKT/PKB signaling pathway. PTENP1 is found on chromosome 9 and regulates PTEN by both sense and antisense RNAs (Gene ID: 101243555). This long-noncoding RNA (lncRNA) acts as a decoy for PTEN targeting microRNAs and also exerts a tumor suppressive activity. [provided by RefSeq, Jun 2020]
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Genomic context

See PTENP1 in Genome Data Viewer
Location:
9p13.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (33673504..33677420, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33673502..33677418, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene T cell receptor beta variable 24/OR9-2 (pseudogene) Neighboring gene T cell receptor beta variable 25/OR9-2 (pseudogene) Neighboring gene PTENP1 antisense RNA Neighboring gene T cell receptor beta variable A/OR9-2 (pseudogene) Neighboring gene T cell receptor beta variable 26/OR9-2 (pseudogene)

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Other Names

  • PTEN/MMAC1 pseudogene
  • phosphatase and tensin homolog (mutated in multiple advanced cancers 1), pseudogene 1
  • phosphatase and tensin homolog pseudogene 1 (functional)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001337.2 

    Range
    67044..70960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_023917.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL356489, BC038293, BY797336
    Related
    ENST00000532280.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    33673504..33677420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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