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CHKA choline kinase alpha [ Homo sapiens (human) ]

Gene ID: 1119, updated on 5-Jul-2025
Official Symbol
CHKAprovided by HGNC
Official Full Name
choline kinase alphaprovided by HGNC
Primary source
HGNC:HGNC:1937
See related
Ensembl:ENSG00000110721 MIM:118491; AllianceGenome:HGNC:1937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CK; EK; CHK; CKI; NEDMIMS
Summary
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 24.3), thyroid (RPKM 9.0) and 25 other tissues See more
Orthologs
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See CHKA in Genome Data Viewer
Location:
11q13.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (68052859..68121388, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (68056500..68125033, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67820326..67888855, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67805851-67806472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3656 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3657 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S8 Neighboring gene microRNA 4691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67817396-67818388 Neighboring gene T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 Neighboring gene microRNA 6753 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:67834020-67834520 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:67850572-67850749 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:67861600-67861729 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:67870988-67871188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67886638-67887154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3658 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67888828-67889593 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67889594-67890360 Neighboring gene CHKA divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr11:67907579-67907779 Neighboring gene lysine methyltransferase 5B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3661 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67981441-67982143

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables choline kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables choline kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables choline kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables choline kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables cholinesterase activity IEA
Inferred from Electronic Annotation
more info
 
enables ethanolamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ethanolamine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ethanolamine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in CDP-choline pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in CDP-choline pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_positive_effect lipid droplet disassembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in lipid transport TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphatidylethanolamine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylethanolamine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphatidylethanolamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
choline kinase alpha
Names
CHETK-alpha
ethanolamine kinase
NP_001268.2
NP_001363148.1
NP_001363149.1
NP_001363150.1
NP_001363151.1
NP_997634.1
XP_047282271.1
XP_047282272.1
XP_047282273.1
XP_047282274.1
XP_047282275.1
XP_047282277.1
XP_047282278.1
XP_047282279.1
XP_054223517.1
XP_054223518.1
XP_054223519.1
XP_054223520.1
XP_054223521.1
XP_054223522.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277.3NP_001268.2  choline kinase alpha isoform a

    See identical proteins and their annotated locations for NP_001268.2

    Status: REVIEWED

    Source sequence(s)
    BC036471, BG703955, BG723115, BI195927, BU617910, D10704
    Consensus CDS
    CCDS8178.1
    UniProtKB/Swiss-Prot
    P35790, Q8NE29
    Related
    ENSP00000265689.4, ENST00000265689.9
    Conserved Domains (1) summary
    cd05156
    Location:111452
    ChoK_euk; Euykaryotic Choline Kinase
  2. NM_001376219.1NP_001363148.1  choline kinase alpha isoform c

    Status: REVIEWED

    Source sequence(s)
    AP002807, AP002992
    Conserved Domains (1) summary
    cd05156
    Location:111462
    ChoK_euk; Euykaryotic Choline Kinase
  3. NM_001376220.1NP_001363149.1  choline kinase alpha isoform d

    Status: REVIEWED

    Source sequence(s)
    AP002807, AP002992
    Conserved Domains (1) summary
    cd05156
    Location:111414
    ChoK_euk; Euykaryotic Choline Kinase
  4. NM_001376221.1NP_001363150.1  choline kinase alpha isoform e

    Status: REVIEWED

    Source sequence(s)
    AP002807, AP002992
    Conserved Domains (1) summary
    cd05156
    Location:1330
    ChoK_euk; Euykaryotic Choline Kinase
  5. NM_001376222.1NP_001363151.1  choline kinase alpha isoform f

    Status: REVIEWED

    Source sequence(s)
    AP002807, AP002992
    Conserved Domains (1) summary
    cd05156
    Location:1312
    ChoK_euk; Euykaryotic Choline Kinase
  6. NM_212469.2NP_997634.1  choline kinase alpha isoform b

    See identical proteins and their annotated locations for NP_997634.1

    Status: REVIEWED

    Source sequence(s)
    AP002807, AP002992
    Consensus CDS
    CCDS8179.1
    UniProtKB/Swiss-Prot
    P35790
    Related
    ENSP00000348454.4, ENST00000356135.9
    Conserved Domains (2) summary
    PLN02236
    Location:99437
    PLN02236; choline kinase
    cd05156
    Location:111434
    ChoK_euk; Euykaryotic Choline Kinase

RNA

  1. NR_164782.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP002807, AP002992

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    68052859..68121388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426315.1XP_047282271.1  choline kinase alpha isoform X1

  2. XM_047426316.1XP_047282272.1  choline kinase alpha isoform X2

  3. XM_047426317.1XP_047282273.1  choline kinase alpha isoform X3

  4. XM_047426318.1XP_047282274.1  choline kinase alpha isoform X4

  5. XM_047426321.1XP_047282277.1  choline kinase alpha isoform X5

  6. XM_047426322.1XP_047282278.1  choline kinase alpha isoform X6

  7. XM_047426319.1XP_047282275.1  choline kinase alpha isoform X5

  8. XM_047426323.1XP_047282279.1  choline kinase alpha isoform X7

RNA

  1. XR_007062448.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    68056500..68125033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367542.1XP_054223517.1  choline kinase alpha isoform X1

  2. XM_054367543.1XP_054223518.1  choline kinase alpha isoform X2

  3. XM_054367544.1XP_054223519.1  choline kinase alpha isoform X3

  4. XM_054367545.1XP_054223520.1  choline kinase alpha isoform X4

  5. XM_054367546.1XP_054223521.1  choline kinase alpha isoform X5

  6. XM_054367547.1XP_054223522.1  choline kinase alpha isoform X7

RNA

  1. XR_008488334.1 RNA Sequence