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MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 [ Homo sapiens (human) ]

Gene ID: 11184, updated on 15-Apr-2019

Summary

Official Symbol
MAP4K1provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 1provided by HGNC
Primary source
HGNC:HGNC:6863
See related
Ensembl:ENSG00000104814 MIM:601983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPK1
Expression
Biased expression in lymph node (RPKM 28.4), spleen (RPKM 19.4) and 10 other tissues See more
Orthologs

Genomic context

See MAP4K1 in Genome Data Viewer
Location:
19q13.2
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (38587640..38618035, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39078281..39108643, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 98 member C Neighboring gene RAS guanyl releasing protein 4 Neighboring gene ryanodine receptor 1 Neighboring gene uncharacterized LOC107985290 Neighboring gene uncharacterized LOC105372397 Neighboring gene eukaryotic translation initiation factor 3 subunit K Neighboring gene actinin alpha 4 Neighboring gene uncharacterized LOC107985291

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
activation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPKKK activity IC
Inferred by Curator
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to phorbol 13-acetate 12-myristate IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase kinase 1
Names
MAPK/ERK kinase kinase kinase 1
MEK kinase kinase 1
MEKKK 1
hematopoietic progenitor kinase 1
NP_001036065.1
NP_009112.1
XP_011524705.1
XP_011524706.1
XP_016881720.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042600.3NP_001036065.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_001036065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (1) has a shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    HY074876, U66464
    Consensus CDS
    CCDS42564.1
    UniProtKB/Swiss-Prot
    Q92918
    Related
    ENSP00000380066.1, ENST00000396857.7
    Conserved Domains (3) summary
    smart00036
    Location:500807
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:17274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  2. NM_007181.5NP_009112.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_009112.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AA995240, HY074876, U66464
    Consensus CDS
    CCDS59385.1
    UniProtKB/Swiss-Prot
    Q92918
    Related
    ENSP00000465039.1, ENST00000591517.5
    Conserved Domains (3) summary
    smart00036
    Location:500807
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:17274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    38587640..38618035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526404.1XP_011524706.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform X2

    Conserved Domains (3) summary
    smart00036
    Location:540847
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:17274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  2. XM_011526403.1XP_011524705.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform X1

    Conserved Domains (3) summary
    smart00036
    Location:540847
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:17274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
  3. XM_017026231.1XP_016881720.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform X3

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_014040929.1 Reference GRCh38.p12 PATCHES

    Range
    1476..27671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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