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BAZ1A bromodomain adjacent to zinc finger domain 1A [ Homo sapiens (human) ]

Gene ID: 11177, updated on 1-Jun-2020

Summary

Official Symbol
BAZ1Aprovided by HGNC
Official Full Name
bromodomain adjacent to zinc finger domain 1Aprovided by HGNC
Primary source
HGNC:HGNC:960
See related
Ensembl:ENSG00000198604 MIM:605680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACF1; WALp1; hACF1; WCRF180
Summary
The BAZ1A gene encodes the accessory subunit of the ATP-dependent chromatin assembly factor (ACF), a member of the ISWI ('imitation switch') family of chromatin remodeling complexes (summarized by Racki et al., 2009 [PubMed 20033039]).[supplied by OMIM, Apr 2010]
Expression
Broad expression in testis (RPKM 18.1), bone marrow (RPKM 15.8) and 24 other tissues See more
Orthologs

Genomic context

See BAZ1A in Genome Data Viewer
Location:
14q13.1-q13.2
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (34752731..34875360, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (35221937..35344853, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene cofilin 2 Neighboring gene ribosomal protein L12 pseudogene 6 Neighboring gene RNA, U7 small nuclear 41 pseudogene Neighboring gene uncharacterized LOC112268124 Neighboring gene SRP54 antisense RNA 1 (head to head) Neighboring gene immunoglobulin (CD79A) binding protein 1 pseudogene 1 Neighboring gene signal recognition particle 54

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of bromodomain adjacent to zinc finger domain, 1A (BAZ1A) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14383, DKFZp586E0518

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT histone acetyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA-dependent DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
chromatin remodeling TAS
Traceable Author Statement
more info
PubMed 
histone acetylation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
ACF complex TAS
Traceable Author Statement
more info
PubMed 
CHRAC IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
bromodomain adjacent to zinc finger domain protein 1A
Names
ATP-dependent chromatin remodeling protein
ATP-utilizing chromatin assembly and remodeling factor 1
CHRAC subunit ACF1
hWALp1
williams syndrome transcription factor-related chromatin-remodeling factor 180

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013448.3NP_038476.2  bromodomain adjacent to zinc finger domain protein 1A isoform a

    See identical proteins and their annotated locations for NP_038476.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AB032252, AF213467, AF221130, AL050089, CB217757
    Consensus CDS
    CCDS9651.1
    UniProtKB/Swiss-Prot
    Q9NRL2
    Related
    ENSP00000353458.1, ENST00000360310.6
    Conserved Domains (7) summary
    cd05504
    Location:14231535
    Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
    smart00571
    Location:422485
    DDT; domain in different transcription and chromosome remodeling factors
    cd15627
    Location:11501195
    PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
    pfam10537
    Location:23122
    WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
    pfam15612
    Location:590635
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:800926
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl26511
    Location:645788
    Neuromodulin_N; Gap junction protein N-terminal region
  2. NM_182648.2NP_872589.1  bromodomain adjacent to zinc finger domain protein 1A isoform b

    See identical proteins and their annotated locations for NP_872589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB032252, AF213467, AF221130, AL050089, CB217757
    Consensus CDS
    CCDS41943.1
    UniProtKB/Swiss-Prot
    Q9NRL2
    Related
    ENSP00000351555.4, ENST00000358716.8
    Conserved Domains (8) summary
    cd05504
    Location:13911503
    Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
    smart00571
    Location:422485
    DDT; domain in different transcription and chromosome remodeling factors
    cd15627
    Location:11181163
    PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
    pfam10537
    Location:23122
    WAC_Acf1_DNA_bd; ATP-utilizing chromatin assembly and remodelling N-terminal
    pfam15612
    Location:560608
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15614
    Location:860898
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    cd16269
    Location:682693
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:617695
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    34752731..34875360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536374.1XP_011534676.1  bromodomain adjacent to zinc finger domain protein 1A isoform X2

    Conserved Domains (7) summary
    cd05504
    Location:13301442
    Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
    smart00571
    Location:329392
    DDT; domain in different transcription and chromosome remodeling factors
    cd15627
    Location:10571102
    PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
    pfam15612
    Location:499547
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15614
    Location:799837
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
    cd16269
    Location:621632
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:556634
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. XM_024449460.1XP_024305228.1  bromodomain adjacent to zinc finger domain protein 1A isoform X1

    Related
    ENSP00000371859.2, ENST00000382422.6
    Conserved Domains (7) summary
    cd05504
    Location:14231535
    Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
    smart00571
    Location:422485
    DDT; domain in different transcription and chromosome remodeling factors
    cd15627
    Location:11501195
    PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
    pfam10537
    Location:23122
    WAC_Acf1_DNA_bd; ATP-utilising chromatin assembly and remodelling N-terminal
    pfam15612
    Location:590635
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:800926
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl26511
    Location:645788
    Neuromodulin_N; Gap junction protein N-terminal region
  3. XM_011536376.3XP_011534678.3  bromodomain adjacent to zinc finger domain protein 1A isoform X3

    Conserved Domains (5) summary
    cd05504
    Location:10191131
    Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
    cd15627
    Location:746791
    PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
    pfam15612
    Location:186231
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:396522
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl26511
    Location:241384
    Neuromodulin_N; Gap junction protein N-terminal region
  4. XM_017020942.2XP_016876431.2  bromodomain adjacent to zinc finger domain protein 1A isoform X4

    Conserved Domains (5) summary
    cd05504
    Location:9871099
    Bromo_Acf1_like; Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) ...
    cd15627
    Location:714759
    PHD_BAZ1A; PHD finger found in bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)
    pfam15612
    Location:154199
    WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1
    pfam15613
    Location:364490
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl26511
    Location:209352
    Neuromodulin_N; Gap junction protein N-terminal region

RNA

  1. XR_943381.1 RNA Sequence

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