U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BAZ2A bromodomain adjacent to zinc finger domain 2A [ Homo sapiens (human) ]

Gene ID: 11176, updated on 22-Sep-2022

Summary

Official Symbol
BAZ2Aprovided by HGNC
Official Full Name
bromodomain adjacent to zinc finger domain 2Aprovided by HGNC
Primary source
HGNC:HGNC:962
See related
Ensembl:ENSG00000076108 MIM:605682; AllianceGenome:HGNC:962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIP5; WALp3
Summary
Enables histone binding activity. Contributes to RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in DNA methylation; histone deacetylation; and negative regulation of macromolecule metabolic process. Predicted to act upstream of or within chromatin organization and histone modification. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 26.6), placenta (RPKM 20.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See BAZ2A in Genome Data Viewer
Location:
12q13.3
Exon count:
38
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56595596..56638318, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56563591..56604356, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56989380..57030143, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 105C Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 4 Neighboring gene RNA binding motif single stranded interacting protein 2 Neighboring gene RNA, U6 small nuclear 343, pseudogene Neighboring gene Sharpr-MPRA regulatory region 9353 Neighboring gene ATP synthase F1 subunit beta Neighboring gene small nucleolar RNA, C/D box 59B Neighboring gene small nucleolar RNA, C/D box 59A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of bromodomain adjacent to zinc finger domain protein 2A (BAZ2A) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13768, FLJ13780, FLJ45876, KIAA0314, DKFZp781B109

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to RNA polymerase I core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lysine-acetylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of NoRC complex IC
Inferred by Curator
more info
 
part_of chromatin silencing complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IC
Inferred by Curator
more info
PubMed 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in rDNA heterochromatin ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
bromodomain adjacent to zinc finger domain protein 2A
Names
TTF-I interacting peptide 5
TTF-I-interacting protein 5
transcription termination factor I-interacting protein 5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300905.2NP_001287834.1  bromodomain adjacent to zinc finger domain protein 2A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter, differs in the 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC090681, AK023842, DB215236
    Consensus CDS
    CCDS73483.1
    UniProtKB/TrEMBL
    F8VU39
    Related
    ENSP00000447941.1, ENST00000549884.6
    Conserved Domains (5) summary
    cd05503
    Location:17961892
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:846911
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:549621
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16761722
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:14371475
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
  2. NM_001351156.2NP_001338085.1  bromodomain adjacent to zinc finger domain protein 2A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes isoform 3.
    Source sequence(s)
    AC090681
    UniProtKB/TrEMBL
    J3QK86
    Related
    ENSP00000368754.3, ENST00000379441.7
    Conserved Domains (7) summary
    cd05503
    Location:17661862
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:816881
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:519591
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16461692
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15613
    Location:14071441
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl26170
    Location:360492
    DUF4115; Domain of unknown function (DUF4115)
    cl27975
    Location:12951398
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
  3. NM_013449.4NP_038477.2  bromodomain adjacent to zinc finger domain protein 2A isoform 1

    See identical proteins and their annotated locations for NP_038477.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC090681, AK023842, CD686304, CR749379
    Consensus CDS
    CCDS44924.1
    UniProtKB/Swiss-Prot
    Q96H26, Q9UIF9
    Related
    ENSP00000446880.1, ENST00000551812.5
    Conserved Domains (5) summary
    cd05503
    Location:17981894
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:848913
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:551623
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16781724
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:14391477
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    56595596..56638318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428142.1XP_047284098.1  bromodomain adjacent to zinc finger domain protein 2A isoform X4

  2. XM_047428148.1XP_047284104.1  bromodomain adjacent to zinc finger domain protein 2A isoform X8

  3. XM_047428155.1XP_047284111.1  bromodomain adjacent to zinc finger domain protein 2A isoform X12

  4. XM_047428151.1XP_047284107.1  bromodomain adjacent to zinc finger domain protein 2A isoform X9

  5. XM_047428145.1XP_047284101.1  bromodomain adjacent to zinc finger domain protein 2A isoform X7

  6. XM_047428166.1XP_047284122.1  bromodomain adjacent to zinc finger domain protein 2A isoform X18

  7. XM_047428144.1XP_047284100.1  bromodomain adjacent to zinc finger domain protein 2A isoform X6

  8. XM_047428141.1XP_047284097.1  bromodomain adjacent to zinc finger domain protein 2A isoform X3

  9. XM_047428139.1XP_047284095.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

  10. XM_047428147.1XP_047284103.1  bromodomain adjacent to zinc finger domain protein 2A isoform X8

  11. XM_047428159.1XP_047284115.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

  12. XM_047428157.1XP_047284113.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

  13. XM_047428164.1XP_047284120.1  bromodomain adjacent to zinc finger domain protein 2A isoform X16

  14. XM_047428163.1XP_047284119.1  bromodomain adjacent to zinc finger domain protein 2A isoform X15

  15. XM_047428153.1XP_047284109.1  bromodomain adjacent to zinc finger domain protein 2A isoform X11

  16. XM_047428158.1XP_047284114.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

  17. XM_047428149.1XP_047284105.1  bromodomain adjacent to zinc finger domain protein 2A isoform X8

  18. XM_047428169.1XP_047284125.1  bromodomain adjacent to zinc finger domain protein 2A isoform X20

  19. XM_047428168.1XP_047284124.1  bromodomain adjacent to zinc finger domain protein 2A isoform X10

    UniProtKB/TrEMBL
    J3QK86
  20. XM_047428167.1XP_047284123.1  bromodomain adjacent to zinc finger domain protein 2A isoform X19

  21. XM_047428162.1XP_047284118.1  bromodomain adjacent to zinc finger domain protein 2A isoform X14

  22. XM_047428161.1XP_047284117.1  bromodomain adjacent to zinc finger domain protein 2A isoform X5

    UniProtKB/TrEMBL
    F8VU39
  23. XM_011537806.3XP_011536108.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    See identical proteins and their annotated locations for XP_011536108.1

    Conserved Domains (5) summary
    cd05503
    Location:18031899
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:846911
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:549621
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16831729
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:14371475
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
  24. XM_017018741.2XP_016874230.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    Conserved Domains (5) summary
    cd05503
    Location:18031899
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:846911
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:549621
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16831729
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:14371475
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
  25. XM_047428150.1XP_047284106.1  bromodomain adjacent to zinc finger domain protein 2A isoform X8

  26. XM_047428165.1XP_047284121.1  bromodomain adjacent to zinc finger domain protein 2A isoform X17

  27. XM_047428156.1XP_047284112.1  bromodomain adjacent to zinc finger domain protein 2A isoform X13

  28. XM_047428154.1XP_047284110.1  bromodomain adjacent to zinc finger domain protein 2A isoform X11

  29. XM_047428146.1XP_047284102.1  bromodomain adjacent to zinc finger domain protein 2A isoform X8

  30. XM_011537805.3XP_011536107.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    See identical proteins and their annotated locations for XP_011536107.1

    Conserved Domains (5) summary
    cd05503
    Location:18031899
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:846911
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:549621
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16831729
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:14371475
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
  31. XM_047428160.1XP_047284116.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

  32. XM_047428143.1XP_047284099.1  bromodomain adjacent to zinc finger domain protein 2A isoform X5

    UniProtKB/TrEMBL
    F8VU39
  33. XM_047428140.1XP_047284096.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

  34. XM_047428152.1XP_047284108.1  bromodomain adjacent to zinc finger domain protein 2A isoform X10

    UniProtKB/TrEMBL
    J3QK86
  35. XM_011537809.3XP_011536111.1  bromodomain adjacent to zinc finger domain protein 2A isoform X21

    Conserved Domains (5) summary
    cd05503
    Location:12551351
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:298363
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:1073
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:11351181
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:889927
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
  36. XM_047428170.1XP_047284126.1  bromodomain adjacent to zinc finger domain protein 2A isoform X22

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    56563591..56604356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)