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BAZ2A bromodomain adjacent to zinc finger domain 2A [ Homo sapiens (human) ]

Gene ID: 11176, updated on 29-Mar-2020

Summary

Official Symbol
BAZ2Aprovided by HGNC
Official Full Name
bromodomain adjacent to zinc finger domain 2Aprovided by HGNC
Primary source
HGNC:HGNC:962
See related
Ensembl:ENSG00000076108 MIM:605682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIP5; WALp3
Expression
Ubiquitous expression in testis (RPKM 26.6), placenta (RPKM 20.1) and 25 other tissues See more
Orthologs

Genomic context

See BAZ2A in Genome Data Viewer
Location:
12q13.3
Exon count:
35
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56595596..56636816, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56989380..57030600, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 105C Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 4 Neighboring gene RNA binding motif single stranded interacting protein 2 Neighboring gene RNA, U6 small nuclear 343, pseudogene Neighboring gene Sharpr-MPRA regulatory region 9353 Neighboring gene ATP synthase F1 subunit beta Neighboring gene small nucleolar RNA, C/D box 59B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of bromodomain adjacent to zinc finger domain protein 2A (BAZ2A) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13768, FLJ13780, FLJ45876, KIAA0314, DKFZp781B109

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase I CORE element sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
lysine-acetylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclear receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA methylation ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase I preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
 
chromatin remodeling NAS
Non-traceable Author Statement
more info
PubMed 
chromatin silencing at rDNA ISS
Inferred from Sequence or Structural Similarity
more info
 
histone deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
chromatin silencing complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
rDNA heterochromatin ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
bromodomain adjacent to zinc finger domain protein 2A
Names
TTF-I interacting peptide 5
TTF-I-interacting protein 5
transcription termination factor I-interacting protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300905.2NP_001287834.1  bromodomain adjacent to zinc finger domain protein 2A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter, differs in the 5' UTR, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC090681, AK023842, DB215236
    Consensus CDS
    CCDS73483.1
    UniProtKB/TrEMBL
    F8VU39
    Related
    ENSP00000447941.1, ENST00000549884.5
    Conserved Domains (5) summary
    cd05503
    Location:17961892
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:846911
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:549621
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16761722
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:14371475
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
  2. NM_001351156.2NP_001338085.1  bromodomain adjacent to zinc finger domain protein 2A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes isoform 3.
    Source sequence(s)
    AC090681
    Related
    ENSP00000368754.3, ENST00000379441.7
    Conserved Domains (7) summary
    cd05503
    Location:17661862
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:816881
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:519591
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16461692
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15613
    Location:14071441
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
    cl26170
    Location:360492
    DUF4115; Domain of unknown function (DUF4115)
    cl27975
    Location:12951398
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
  3. NM_013449.4NP_038477.2  bromodomain adjacent to zinc finger domain protein 2A isoform 1

    See identical proteins and their annotated locations for NP_038477.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC090681, AK023842, CD686304, CR749379
    Consensus CDS
    CCDS44924.1
    UniProtKB/Swiss-Prot
    Q9UIF9
    Related
    ENSP00000446880.1, ENST00000551812.5
    Conserved Domains (5) summary
    cd05503
    Location:17981894
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:848913
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:551623
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16781724
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:14391477
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    56595596..56636816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537804.2XP_011536106.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    See identical proteins and their annotated locations for XP_011536106.1

    Conserved Domains (5) summary
    cd05503
    Location:18031899
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:846911
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:549621
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16831729
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:14371475
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
  2. XM_011537801.2XP_011536103.1  bromodomain adjacent to zinc finger domain protein 2A isoform X1

    Conserved Domains (5) summary
    cd05503
    Location:18051901
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:848913
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:551623
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16851731
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:14391477
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
  3. XM_017018740.1XP_016874229.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    Conserved Domains (5) summary
    cd05503
    Location:18031899
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:846911
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:549621
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16831729
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:14371475
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
  4. XM_011537806.2XP_011536108.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    See identical proteins and their annotated locations for XP_011536108.1

    Conserved Domains (5) summary
    cd05503
    Location:18031899
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:846911
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:549621
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16831729
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:14371475
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
  5. XM_017018741.1XP_016874230.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    Conserved Domains (5) summary
    cd05503
    Location:18031899
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:846911
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:549621
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16831729
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:14371475
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
  6. XM_011537803.2XP_011536105.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    See identical proteins and their annotated locations for XP_011536105.1

    Conserved Domains (5) summary
    cd05503
    Location:18031899
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:846911
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:549621
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16831729
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:14371475
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
  7. XM_011537805.2XP_011536107.1  bromodomain adjacent to zinc finger domain protein 2A isoform X2

    See identical proteins and their annotated locations for XP_011536107.1

    Conserved Domains (5) summary
    cd05503
    Location:18031899
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:846911
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:549621
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:16831729
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:14371475
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
  8. XM_011537809.2XP_011536111.1  bromodomain adjacent to zinc finger domain protein 2A isoform X3

    Conserved Domains (5) summary
    cd05503
    Location:12551351
    Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
    smart00571
    Location:298363
    DDT; domain in different transcription and chromosome remodeling factors
    cd01397
    Location:1073
    HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
    cd15629
    Location:11351181
    PHD_BAZ2A; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A)
    pfam15614
    Location:889927
    WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
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