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INSL6 insulin like 6 [ Homo sapiens (human) ]

Gene ID: 11172, updated on 11-Jun-2021


Official Symbol
INSL6provided by HGNC
Official Full Name
insulin like 6provided by HGNC
Primary source
See related
Ensembl:ENSG00000120210 MIM:606414
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development and fertilization. [provided by RefSeq, Jul 2008]
Restricted expression toward testis (RPKM 6.0) See more
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Genomic context

See INSL6 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (4992409..5185707, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (5163868..5185639, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RNA terminal phosphate cyclase like 1 Neighboring gene microRNA 101-2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 41 Neighboring gene Sharpr-MPRA regulatory region 14989 Neighboring gene Janus kinase 2 Neighboring gene casein kinase 1 gamma 2 pseudogene 1 Neighboring gene uncharacterized LOC107987044 Neighboring gene MT-ND5 pseudogene 36 Neighboring gene MT-ATP6 pseudogene 11 Neighboring gene decaprenyl diphosphate synthase subunit 1 pseudogene 1 Neighboring gene MT-ND1 pseudogene 11 Neighboring gene MT-ND2 pseudogene 36 Neighboring gene MT-CO1 pseudogene 11 Neighboring gene MT-CO2 pseudogene 11 Neighboring gene MT-ND6 pseudogene 5 Neighboring gene MT-CO3 pseudogene 11 Neighboring gene MT-ND3 pseudogene 14 Neighboring gene MT-ND4L pseudogene 6 Neighboring gene MT-ND4 pseudogene 14 Neighboring gene MT-ND5 pseudogene 14 Neighboring gene transcription factor 3 pseudogene 1 Neighboring gene immunoglobulin heavy constant epsilon P2 (pseudogene) Neighboring gene INSL4 promoter region Neighboring gene insulin like 4 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 31 Neighboring gene relaxin 2

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


Associated conditions

Description Tests
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
GeneReviews: Not available


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity NAS
Non-traceable Author Statement
more info
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
located_in extracellular region IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
insulin-like peptide INSL6
insulin-like peptide 5
insulin-like peptide 6
relaxin/insulin-like factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NG_046969.1 RefSeqGene

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007179.3NP_009110.2  insulin-like peptide INSL6 precursor

    See identical proteins and their annotated locations for NP_009110.2

    Status: REVIEWED

    Source sequence(s)
    AF156094, AL161450, AW117587
    Consensus CDS
    ENSP00000371054.3, ENST00000381641.4
    Conserved Domains (1) summary
    IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    4992409..5185707 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517702.3XP_011516004.1  insulin-like peptide INSL6 isoform X1

    Conserved Domains (1) summary
    IlGF_like; Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig ...
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