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STRAP serine/threonine kinase receptor associated protein [ Homo sapiens (human) ]

Gene ID: 11171, updated on 6-Sep-2022

Summary

Official Symbol
STRAPprovided by HGNC
Official Full Name
serine/threonine kinase receptor associated proteinprovided by HGNC
Primary source
HGNC:HGNC:30796
See related
Ensembl:ENSG00000023734 MIM:605986; AllianceGenome:HGNC:30796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAWD; PT-WD; UNRIP
Summary
Enables RNA binding activity. Involved in maintenance of gastrointestinal epithelium; negative regulation of transforming growth factor beta receptor signaling pathway; and spliceosomal snRNP assembly. Located in cytosol. Part of SMN complex. Implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 51.3), thyroid (RPKM 49.9) and 25 other tissues See more
Orthologs
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Genomic context

See STRAP in Genome Data Viewer
Location:
12p12.3
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (15882387..15903478)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (15759643..15780736)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (16035321..16056412)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724146 Neighboring gene mitochondrial ribosomal protein S7 pseudogene 2 Neighboring gene deoxyribose-phosphate aldolase Neighboring gene egl-9 family hypoxia-inducible factor 3 pseudogene 1 Neighboring gene VISTA enhancer hs798

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag HIV-1 NC is identified to have a physical interaction with serine/threonine kinase receptor associated protein (STRAP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables U2 snRNP binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of SMN complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SMN complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SMN complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of SMN-Sm protein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine-threonine kinase receptor-associated protein
Names
MAP activator with WD repeats
MAPK activator with WD repeats
WD-40 repeat protein PT-WD
mitogen-activated protein kinase activator with WD repeats
unr-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007178.4NP_009109.3  serine-threonine kinase receptor-associated protein

    See identical proteins and their annotated locations for NP_009109.3

    Status: VALIDATED

    Source sequence(s)
    AC022073
    Consensus CDS
    CCDS8676.1
    UniProtKB/Swiss-Prot
    Q9UQC8, Q9Y3F4
    Related
    ENSP00000392270.2, ENST00000419869.7
    Conserved Domains (2) summary
    cd00200
    Location:9293
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:104141
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    15882387..15903478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    15759643..15780736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)