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SOX21 SRY-box transcription factor 21 [ Homo sapiens (human) ]

Gene ID: 11166, updated on 27-Nov-2024

Summary

Official Symbol
SOX21provided by HGNC
Official Full Name
SRY-box transcription factor 21provided by HGNC
Primary source
HGNC:HGNC:11197
See related
Ensembl:ENSG00000125285 MIM:604974; AllianceGenome:HGNC:11197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SOX25
Summary
SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM, Apr 2004]
Orthologs
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Genomic context

See SOX21 in Genome Data Viewer
Location:
13q32.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (94709622..94712545, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (93913127..93916050, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (95361876..95364799, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 36 Neighboring gene NANOG hESC enhancer GRCh37_chr13:95313022-95313523 Neighboring gene VISTA enhancer hs796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:95353695-95354372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:95354373-95355048 Neighboring gene long intergenic non-protein coding RNA 391 Neighboring gene RNA, 7SL, cytoplasmic 585, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:95357234-95357738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:95357739-95358243 Neighboring gene VISTA enhancer hs488 Neighboring gene uncharacterized LOC112268114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:95365523-95366024 Neighboring gene SOX21 antisense divergent transcript 1 Neighboring gene bromodomain containing 7 pseudogene 5

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hair follicle development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in stem cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
transcription factor SOX-21
Names
SOX-A
SRY (sex determining region Y)-box 21
SRY-box 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007084.4NP_009015.1  transcription factor SOX-21

    See identical proteins and their annotated locations for NP_009015.1

    Status: VALIDATED

    Source sequence(s)
    AI418194, AL137061, CX869660, DB493621, DB542438, HY124230
    Consensus CDS
    CCDS9473.1
    UniProtKB/Swiss-Prot
    P35715, Q15504, Q5TBS1, Q9Y651
    Related
    ENSP00000366144.2, ENST00000376945.4
    Conserved Domains (2) summary
    cd01388
    Location:778
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam12336
    Location:7795
    SOXp; SOX transcription factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    94709622..94712545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    93913127..93916050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)