Format

Send to:

Choose Destination

NUDT6 nudix hydrolase 6 [ Homo sapiens (human) ]

Gene ID: 11162, updated on 8-Dec-2018

Summary

Official Symbol
NUDT6provided by HGNC
Official Full Name
nudix hydrolase 6provided by HGNC
Primary source
HGNC:HGNC:8053
See related
Ensembl:ENSG00000170917 MIM:606261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GFG1; GFG-1; ASFGF2; FGF-AS; FGF2AS
Summary
This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in fat (RPKM 12.5), kidney (RPKM 8.8) and 23 other tissues See more
Orthologs

Genomic context

See NUDT6 in Genome Data Viewer
Location:
4q28.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (122892644..122923004, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (123813799..123844159, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene FGF2 promoter region Neighboring gene ribosomal protein S26 pseudogene 23 Neighboring gene fibroblast growth factor 2 Neighboring gene spermatogenesis associated 5 Neighboring gene coilin pseudogene 2 Neighboring gene uncharacterized LOC105377404

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP-ribose diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NADH pyrophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nucleoside diphosphate-linked moiety X motif 6
Names
antisense basic fibroblast growth factor
nudix (nucleoside diphosphate linked moiety X)-type motif 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030404.1 RefSeqGene

    Range
    5001..35361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007083.4NP_009014.2  nucleoside diphosphate-linked moiety X motif 6 isoform a

    See identical proteins and their annotated locations for NP_009014.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF019633, BC009842, BG386740, CB128685
    Consensus CDS
    CCDS43268.1
    UniProtKB/Swiss-Prot
    P53370
    Related
    ENSP00000306070.5, ENST00000304430.9
    Conserved Domains (1) summary
    cd04670
    Location:142275
    Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
  2. NM_198041.2NP_932158.1  nucleoside diphosphate-linked moiety X motif 6 isoform b

    See identical proteins and their annotated locations for NP_932158.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AF019632, AK294450, BC009842
    Consensus CDS
    CCDS3729.1
    UniProtKB/Swiss-Prot
    P53370
    UniProtKB/TrEMBL
    B4DG76
    Related
    ENSP00000344011.2, ENST00000339154.6
    Conserved Domains (1) summary
    cl00447
    Location:1106
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    122892644..122923004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center