Format

Send to:

Choose Destination

PTP4A3 protein tyrosine phosphatase type IVA, member 3 [ Homo sapiens (human) ]

Gene ID: 11156, updated on 8-Dec-2018

Summary

Official Symbol
PTP4A3provided by HGNC
Official Full Name
protein tyrosine phosphatase type IVA, member 3provided by HGNC
Primary source
HGNC:HGNC:9636
See related
Ensembl:ENSG00000184489 MIM:606449
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRL3; PRL-3; PRL-R
Summary
This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Broad expression in heart (RPKM 28.7), prostate (RPKM 11.1) and 20 other tissues See more
Orthologs

Genomic context

See PTP4A3 in Genome Data Viewer
Location:
8q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (141391995..141432454)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (142402093..142442554)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928037 Neighboring gene uncharacterized LOC105375790 Neighboring gene VISTA enhancer hs1882 Neighboring gene uncharacterized LOC107983985 Neighboring gene uncharacterized LOC105375789 Neighboring gene maestro heat like repeat family member 5 (gene/pseudogene) Neighboring gene heterogeneous nuclear ribonucleoprotein A1pseudogene 38

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
prenylated protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
early endosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein tyrosine phosphatase type IVA 3
Names
phosphatase of regenerating liver 3
potentially prenylated protein tyrosine phosphatase
protein-tyrosine phosphatase 4a3
protein-tyrosine phosphatase of regenerating liver 3
NP_009010.2
NP_116000.1
XP_005250821.1
XP_006716563.1
XP_011515105.1
XP_011515107.1
XP_016868487.1
XP_016868488.1
XP_024302825.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007079.3NP_009010.2  protein tyrosine phosphatase type IVA 3 isoform 2

    See identical proteins and their annotated locations for NP_009010.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC100803, AK311257, BC003105
    Consensus CDS
    CCDS6382.1
    UniProtKB/Swiss-Prot
    O75365
    Related
    ENSP00000331730.1, ENST00000349124.2
    Conserved Domains (1) summary
    cl21483
    Location:11148
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_032611.2NP_116000.1  protein tyrosine phosphatase type IVA 3 isoform 1

    See identical proteins and their annotated locations for NP_116000.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC100803, AK311257, BC003105, BQ637038
    Consensus CDS
    CCDS6383.1
    UniProtKB/Swiss-Prot
    O75365
    Related
    ENSP00000332274.1, ENST00000329397.5
    Conserved Domains (1) summary
    cl21483
    Location:11173
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    141391995..141432454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012998.2XP_016868487.1  protein tyrosine phosphatase type IVA 3 isoform X3

    UniProtKB/Swiss-Prot
    O75365
    Related
    ENSP00000428758.1, ENST00000520105.5
    Conserved Domains (1) summary
    cl21483
    Location:11148
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. XM_006716500.3XP_006716563.1  protein tyrosine phosphatase type IVA 3 isoform X2

    See identical proteins and their annotated locations for XP_006716563.1

    Conserved Domains (1) summary
    cl21483
    Location:5149
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. XM_017012999.2XP_016868488.1  protein tyrosine phosphatase type IVA 3 isoform X4

  4. XM_011516805.1XP_011515107.1  protein tyrosine phosphatase type IVA 3 isoform X1

    See identical proteins and their annotated locations for XP_011515107.1

    UniProtKB/Swiss-Prot
    O75365
    Conserved Domains (1) summary
    cl21483
    Location:11173
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  5. XM_011516803.1XP_011515105.1  protein tyrosine phosphatase type IVA 3 isoform X1

    See identical proteins and their annotated locations for XP_011515105.1

    UniProtKB/Swiss-Prot
    O75365
    Conserved Domains (1) summary
    cl21483
    Location:11173
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  6. XM_005250764.2XP_005250821.1  protein tyrosine phosphatase type IVA 3 isoform X1

    See identical proteins and their annotated locations for XP_005250821.1

    UniProtKB/Swiss-Prot
    O75365
    Conserved Domains (1) summary
    cl21483
    Location:11173
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  7. XM_024447057.1XP_024302825.1  protein tyrosine phosphatase type IVA 3 isoform X1

    Conserved Domains (1) summary
    cl21483
    Location:11173
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187574.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    93844..104910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center