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FICD FIC domain protein adenylyltransferase [ Homo sapiens (human) ]

Gene ID: 11153, updated on 6-Jan-2026
Official Symbol
FICDprovided by HGNC
Official Full Name
FIC domain protein adenylyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:18416
See related
Ensembl:ENSG00000198855 MIM:620875; AllianceGenome:HGNC:18416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HYPE; HIP13; SPG92; UNQ3041
Summary
Enables several functions, including AMPylase activity; ATP binding activity; and Hsp70 protein binding activity. Involved in protein adenylylation; regulation of IRE1-mediated unfolded protein response; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in thyroid (RPKM 7.5), testis (RPKM 4.5) and 25 other tissues See more
Orthologs
mouse all
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See FICD in Genome Data Viewer
Location:
12q23.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (108515277..108521210)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (108484639..108490575)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (108909054..108914987)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:108697351-108697872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:108699443-108699964 Neighboring gene chemerin chemokine-like receptor 1 Neighboring gene Sharpr-MPRA regulatory region 8395 Neighboring gene Sharpr-MPRA regulatory region 632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108732521-108733144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108739700-108740200 Neighboring gene MPRA-validated peak1933 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:108780158-108781357 Neighboring gene Sharpr-MPRA regulatory region 8786 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:108811567-108812766 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:108835174-108835930 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:108835931-108836688 Neighboring gene MPRA-validated peak1935 silencer Neighboring gene long intergenic non-protein coding RNA 1498 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:108906844-108907029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108910488-108910988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108910989-108911489 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:108918373-108919572 Neighboring gene MPRA-validated peak1936 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4827 Neighboring gene spliceosome associated factor 3, U4/U6 recycling protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6969 Neighboring gene iron-sulfur cluster assembly enzyme

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. BiP inactivation due to loss of the deAMPylation function of FICD causes a motor neuron disease. Rebelo AP, et al. Genet Med, 2022 Dec. PMID 36136088
  2. Investigation of the Detailed AMPylated Reaction Mechanism for the Huntingtin Yeast-Interacting Protein E Enzyme HYPE. Liu M, et al. Int J Mol Sci, 2021 Jun 29. PMID 34209803, Free PMC Article
  3. Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach. Broncel M, et al. Mol Cell Proteomics, 2016 Feb. PMID 26604261, Free PMC Article
  4. Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD. Fauser J, et al. Nat Commun, 2021 Apr 23. PMID 33893288, Free PMC Article
  5. A Fluorescence Polarization-Based High-Throughput Screen to Identify the First Small-Molecule Modulators of the Human Adenylyltransferase HYPE/FICD. Camara A, et al. Int J Mol Sci, 2020 Sep 27. PMID 32992526, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD.
    Title: Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD.
  2. Investigation of the Detailed AMPylated Reaction Mechanism for the Huntingtin Yeast-Interacting Protein E Enzyme HYPE.
    Title: Investigation of the Detailed AMPylated Reaction Mechanism for the Huntingtin Yeast-Interacting Protein E Enzyme HYPE.
  3. Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD.
    Title: Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD.
  4. A Fluorescence Polarization-Based High-Throughput Screen to Identify the First Small-Molecule Modulators of the Human Adenylyltransferase HYPE/FICD.
    Title: A Fluorescence Polarization-Based High-Throughput Screen to Identify the First Small-Molecule Modulators of the Human Adenylyltransferase HYPE/FICD.
  5. FICD-dependent AMPylation remodelling accelerates differentiation of neural progenitor cells into mature neurons.
    Title: FICD activity and AMPylation remodelling modulate human neurogenesis.
  6. The single catalytic domain of FICD can release the attached AMP, restoring functionality to BiP.
    Title: FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP.
  7. We first demonstrate efficient enrichment and fast visualization of potential HYPE substrates in cell lysates by in-gel fluorescence, followed by robust identification via shotgun proteomics on a QExactive mass spectrometer
    Title: Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach.
  8. HYPE is an unfolded protein response regulator.
    Title: A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC5623

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables AMPylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables AMPylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables AMPylase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein adenylylhydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein adenylylhydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein adenylylhydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-folding chaperone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein adenylylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein adenylylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deadenylylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of IRE1-mediated unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of IRE1-mediated unfolded protein response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of IRE1-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
  
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein adenylyltransferase FICD
Names
AMPylase
AMPylator FICD
FIC domain containing
FIC domain-containing protein
HIP-13
Huntingtin interacting protein E
adenosine monophosphate-protein transferase FICD
de-AMPylase FICD
fic S-phase protein cell division homolog
huntingtin interactor protein E
huntingtin yeast partner E
huntingtin-interacting protein 13
huntingtin-interacting protein E
NP_009007.2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007076.3 → NP_009007.2  protein adenylyltransferase FICD

    See identical proteins and their annotated locations for NP_009007.2

    Status: VALIDATED

    Source sequence(s)
    AC010206, AF049611, AK026074, BC001342
    Consensus CDS
    CCDS9116.1
    UniProtKB/Swiss-Prot
    O75406, Q9BVA6
    Related
    ENSP00000446479.1, ENST00000552695.6
    Conserved Domains (4) summary
    COG3177
    Location:227 → 430
    COG3177; Fic family protein [Transcription]
    sd00006
    Location:106 → 134
    TPR; TPR repeat [structural motif]
    pfam02661
    Location:285 → 381
    Fic; Fic/DOC family
    pfam13414
    Location:105 → 171
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    108515277..108521210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    108484639..108490575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BVA6.2 GenPept UniProtKB/Swiss-Prot:Q9BVA6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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