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PKIG cAMP-dependent protein kinase inhibitor gamma [ Homo sapiens (human) ]

Gene ID: 11142, updated on 13-Mar-2020

Summary

Official Symbol
PKIGprovided by HGNC
Official Full Name
cAMP-dependent protein kinase inhibitor gammaprovided by HGNC
Primary source
HGNC:HGNC:9019
See related
Ensembl:ENSG00000168734 MIM:604932
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKI-gamma
Summary
This gene encodes a member of the protein kinase inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive cAMP-dependent protein kinase inhibitor, and is a predominant form of inhibitor in various tissues. The encoded protein may be involved in osteogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in heart (RPKM 51.1), urinary bladder (RPKM 28.8) and 24 other tissues See more
Orthologs

Genomic context

See PKIG in Genome Data Viewer
Location:
20q13.12
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (44531781..44619037)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43160422..43247678)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene alpha tocopherol transfer protein like Neighboring gene serine incorporator 3 Neighboring gene Sharpr-MPRA regulatory region 7879 Neighboring gene adenosine deaminase intronic regulatory elements Neighboring gene adenosine deaminase Neighboring gene proximal ADA Alu-mediated recombination region Neighboring gene distal ADA Alu-mediated recombination region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126458, MGC126459

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cAMP-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cAMP-dependent protein kinase inhibitor gamma
Names
protein kinase (cAMP-dependent, catalytic) inhibitor gamma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281444.1NP_001268373.1  cAMP-dependent protein kinase inhibitor gamma

    See identical proteins and their annotated locations for NP_001268373.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. Variants 1-5 encode the same protein.
    Source sequence(s)
    AI140360, BG388302, BI461377, CD244921, CN354542
    Consensus CDS
    CCDS13334.1
    UniProtKB/Swiss-Prot
    Q9Y2B9
    UniProtKB/TrEMBL
    Q549H9
    Related
    ENSP00000361980.1, ENST00000372889.5
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  2. NM_001281445.2NP_001268374.1  cAMP-dependent protein kinase inhibitor gamma

    See identical proteins and their annotated locations for NP_001268374.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 4. Variants 1-5 encode the same protein.
    Source sequence(s)
    AA463287, BQ010165, DN994035
    Consensus CDS
    CCDS13334.1
    UniProtKB/Swiss-Prot
    Q9Y2B9
    UniProtKB/TrEMBL
    Q549H9
    Related
    ENSP00000361977.1, ENST00000372886.6
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  3. NM_007066.5NP_008997.1  cAMP-dependent protein kinase inhibitor gamma

    See identical proteins and their annotated locations for NP_008997.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 4. Variants 1-5 encode the same protein.
    Source sequence(s)
    BC104257, Z97053
    Consensus CDS
    CCDS13334.1
    UniProtKB/Swiss-Prot
    Q9Y2B9
    UniProtKB/TrEMBL
    Q549H9
    Related
    ENSP00000361985.3, ENST00000372894.7
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  4. NM_181804.2NP_861520.1  cAMP-dependent protein kinase inhibitor gamma

    See identical proteins and their annotated locations for NP_861520.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 4. Variants 1-5 encode the same protein.
    Source sequence(s)
    AI140360, CD244921, CN354542
    Consensus CDS
    CCDS13334.1
    UniProtKB/Swiss-Prot
    Q9Y2B9
    UniProtKB/TrEMBL
    Q549H9
    Related
    ENSP00000361983.3, ENST00000372892.7
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  5. NM_181805.2NP_861521.1  cAMP-dependent protein kinase inhibitor gamma

    See identical proteins and their annotated locations for NP_861521.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 4. Variants 1-5 encode the same protein.
    Source sequence(s)
    BG717090, BQ010165, CN354542
    Consensus CDS
    CCDS13334.1
    UniProtKB/Swiss-Prot
    Q9Y2B9
    UniProtKB/TrEMBL
    Q549H9
    Related
    ENSP00000361981.3, ENST00000372891.7
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    44531781..44619037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027615.1XP_016883104.1  cAMP-dependent protein kinase inhibitor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q9Y2B9
    UniProtKB/TrEMBL
    Q549H9
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  2. XM_017027616.1XP_016883105.1  cAMP-dependent protein kinase inhibitor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q9Y2B9
    UniProtKB/TrEMBL
    Q549H9
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
  3. XM_017027614.1XP_016883103.1  cAMP-dependent protein kinase inhibitor gamma isoform X1

    UniProtKB/Swiss-Prot
    Q9Y2B9
    UniProtKB/TrEMBL
    Q549H9
    Conserved Domains (1) summary
    pfam02827
    Location:270
    PKI; cAMP-dependent protein kinase inhibitor
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