Format

Send to:

Choose Destination

CDC37 cell division cycle 37 [ Homo sapiens (human) ]

Gene ID: 11140, updated on 12-Aug-2018

Summary

Official Symbol
CDC37provided by HGNC
Official Full Name
cell division cycle 37provided by HGNC
Primary source
HGNC:HGNC:1735
See related
Ensembl:ENSG00000105401 MIM:605065; Vega:OTTHUMG00000180578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P50CDC37
Summary
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 70.6), spleen (RPKM 61.9) and 25 other tissues See more
Orthologs

Genomic context

See CDC37 in Genome Data Viewer
Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (10391128..10403595, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10501809..10514271, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene intercellular adhesion molecule 3 Neighboring gene tyrosine kinase 2 Neighboring gene microRNA 1181 Neighboring gene phosphodiesterase 4A Neighboring gene kelch like ECH associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Aryl Hydrocarbon Receptor, organism-specific biosystem (from WikiPathways)
    Aryl Hydrocarbon Receptor, organism-specific biosystemThe Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression. The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or...
  • Aryl Hydrocarbon Receptor Pathway, organism-specific biosystem (from WikiPathways)
    Aryl Hydrocarbon Receptor Pathway, organism-specific biosystemThe aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic m...
  • Constitutive Signaling by EGFRvIII, organism-specific biosystem (from REACTOME)
    Constitutive Signaling by EGFRvIII, organism-specific biosystemIn glioblastoma, the most prevalent EGFR mutation, present in ~25% of tumors, is the deletion of the ligand binding domain of EGFR, accompanied with amplification of the mutated allele, which results...
  • Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, organism-specific biosystem (from REACTOME)
    Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, organism-specific biosystemSignaling by EGFR is frequently activated in cancer through activating mutations in the coding sequence of the EGFR gene, resulting in expression of a constitutively active mutant protein. Epidermal ...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
    Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
  • Downregulation of ERBB2 signaling, organism-specific biosystem (from REACTOME)
    Downregulation of ERBB2 signaling, organism-specific biosystemSignaling by ERBB2 can be downregulated by ubiquitination and subsequent proteasome-dependent degradation of ERBB2 or activated ERBB2 heterodimers. In addition, protein tyrosine phosphatases that dep...
  • LKB1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    LKB1 signaling events, organism-specific biosystem
    LKB1 signaling events
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
    Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows signaling by constitutively active EGFR cancer variants in the context of "Signaling by EGFR", allowing users to compare cancer events with the wild-ty...
  • Signaling by EGFRvIII in Cancer, organism-specific biosystem (from REACTOME)
    Signaling by EGFRvIII in Cancer, organism-specific biosystemEGFRvIII (EGFR V30_R297delinsG) is the most prevalent EGFR variant in glioblastoma, but it is also found in other cancer types. In-frame deletion of the ligand binding domain in EGFRvIII is frequentl...
  • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
    Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
  • Signaling by Ligand-Responsive EGFR Variants in Cancer, organism-specific biosystem (from REACTOME)
    Signaling by Ligand-Responsive EGFR Variants in Cancer, organism-specific biosystemLigand-responsive EGFR cancer variants harbor mutations in the kinase domain or point mutations in the extracellular domain. These altered EGFR proteins are able to signal in the absence of ligands, ...
  • Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystem (from WikiPathways)
    Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystemThis pathway Involved in chemo-resistance of cells in bladder cancer begins with LOXL2 activation of CDC37 and COL2A1. COL2A1 activates the complex NRF1/2 and two other complexes that trigger RTK/MAP...
  • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Hsp90 protein binding IEA
Inferred from Electronic Annotation
more info
 
chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ERBB2 signaling pathway TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitophagy in response to mitochondrial depolarization IEA
Inferred from Electronic Annotation
more info
 
posttranscriptional regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting TAS
Traceable Author Statement
more info
PubMed 
regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
regulation of interferon-gamma-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
HSP90-CDC37 chaperone complex IEA
Inferred from Electronic Annotation
more info
 
chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
hsp90 co-chaperone Cdc37
Names
CDC37 (cell division cycle 37, S. cerevisiae, homolog)
CDC37 cell division cycle 37 homolog
cell division cycle 37 homolog
hsp90 chaperone protein kinase-targeting subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007065.3NP_008996.1  hsp90 co-chaperone Cdc37

    See identical proteins and their annotated locations for NP_008996.1

    Status: REVIEWED

    Source sequence(s)
    BC000083, BE796008
    Consensus CDS
    CCDS12237.1
    UniProtKB/Swiss-Prot
    Q16543
    UniProtKB/TrEMBL
    A0A024R7B7
    Related
    ENSP00000222005.1, OTTHUMP00000264657, ENST00000222005.6, OTTHUMT00000451987
    Conserved Domains (3) summary
    smart01071
    Location:1127
    CDC37_N; Cdc37 N terminal kinase binding
    smart01069
    Location:287377
    CDC37_C; Cdc37 C terminal domain
    smart01070
    Location:133275
    CDC37_M; Cdc37 Hsp90 binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    10391128..10403595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527652.3XP_011525954.1  hsp90 co-chaperone Cdc37 isoform X1

    Related
    ENSP00000465724.1, OTTHUMP00000264661, ENST00000593124.1
    Conserved Domains (3) summary
    smart01071
    Location:1126
    CDC37_N; Cdc37 N terminal kinase binding
    smart01069
    Location:338428
    CDC37_C; Cdc37 C terminal domain
    smart01070
    Location:184326
    CDC37_M; Cdc37 Hsp90 binding domain
Support Center