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CAPN11 calpain 11 [ Homo sapiens (human) ]

Gene ID: 11131, updated on 25-Jan-2022

Summary

Official Symbol
CAPN11provided by HGNC
Official Full Name
calpain 11provided by HGNC
Primary source
HGNC:HGNC:1478
See related
Ensembl:ENSG00000137225 MIM:604822; AllianceGenome:HGNC:1478
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
calpain11
Summary
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]
Expression
Restricted expression toward testis (RPKM 18.7) See more
Orthologs
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Genomic context

See CAPN11 in Genome Data Viewer
Location:
6p21.1
Exon count:
25
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (44158811..44184401)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (44126557..44152138)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA polymerase I and III subunit C Neighboring gene uncharacterized LOC107986599 Neighboring gene uncharacterized LOC105375072 Neighboring gene mitochondrial ribosomal protein L14 Neighboring gene transmembrane protein 63B Neighboring gene RNA, 7SL, cytoplasmic 811, pseudogene Neighboring gene myomixer, myoblast fusion factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
calpain-11
Names
CANP 11
calcium-activated neutral proteinase 11
NP_008989.2
XP_006715047.1
XP_006715048.1
XP_006715050.1
XP_011512576.1
XP_011512577.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007058.4NP_008989.2  calpain-11

    See identical proteins and their annotated locations for NP_008989.2

    Status: REVIEWED

    Source sequence(s)
    AJ242832, BC033733, DB052011
    Consensus CDS
    CCDS47436.1
    UniProtKB/Swiss-Prot
    Q9UMQ6
    Related
    ENSP00000381758.1, ENST00000398776.2
    Conserved Domains (3) summary
    pfam00648
    Location:80376
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:390544
    Calpain_III; Calpain large subunit, domain III
    cl08302
    Location:615665
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    44158811..44184401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714984.1XP_006715047.1  calpain-11 isoform X1

    Conserved Domains (3) summary
    pfam00648
    Location:81377
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:391545
    Calpain_III; Calpain large subunit, domain III
    cl08302
    Location:616666
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. XM_006714985.1XP_006715048.1  calpain-11 isoform X2

    Conserved Domains (3) summary
    pfam00648
    Location:81377
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:391545
    Calpain_III; Calpain large subunit, domain III
    cl08302
    Location:616666
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. XM_006714987.1XP_006715050.1  calpain-11 isoform X5

    Conserved Domains (2) summary
    pfam00648
    Location:81377
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:391545
    Calpain_III; Calpain large subunit, domain III
  4. XM_011514275.1XP_011512577.1  calpain-11 isoform X4

    Conserved Domains (3) summary
    pfam00648
    Location:84380
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:394548
    Calpain_III; Calpain large subunit, domain III
    cl08302
    Location:619669
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  5. XM_011514274.1XP_011512576.1  calpain-11 isoform X3

    Conserved Domains (3) summary
    pfam00648
    Location:85381
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:395549
    Calpain_III; Calpain large subunit, domain III
    cl08302
    Location:620670
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RNA

  1. XR_001743135.1 RNA Sequence

  2. XR_001743136.1 RNA Sequence

  3. XR_926042.1 RNA Sequence

  4. XR_001743134.1 RNA Sequence

  5. XR_926043.1 RNA Sequence

  6. XR_926044.1 RNA Sequence

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