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POLR3A RNA polymerase III subunit A [ Homo sapiens (human) ]

Gene ID: 11128, updated on 17-Jun-2019

Summary

Official Symbol
POLR3Aprovided by HGNC
Official Full Name
RNA polymerase III subunit Aprovided by HGNC
Primary source
HGNC:HGNC:30074
See related
Ensembl:ENSG00000148606 MIM:614258
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADDH; HLD7; RPC1; WDRTS; RPC155; hRPC155
Summary
The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in brain (RPKM 7.2), testis (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See POLR3A in Genome Data Viewer
Location:
10q22.3
Exon count:
31
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (77975149..78029515, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (79734907..79789298, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H2A histone family member Z pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 9595 Neighboring gene ribosomal protein S24 Neighboring gene G protein subunit alpha i2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of polymerase (RNA) III (DNA directed) polypeptide A, (POLR3A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA-directed 5'-3' RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-directed 5'-3' RNA polymerase activity NAS
Non-traceable Author Statement
more info
PubMed 
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase III subunit RPC1
Names
DNA-directed RNA polymerase III largest subunit
DNA-directed RNA polymerase III subunit A
RNA polymerase III 155 kDa subunit
RNA polymerase III subunit C1
RNA polymerase III subunit C160
RNA polymerase III subunit RPC155-D
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
polymerase (RNA) III subunit A
NP_008986.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029648.1 RefSeqGene

    Range
    5001..59392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007055.4NP_008986.2  DNA-directed RNA polymerase III subunit RPC1

    See identical proteins and their annotated locations for NP_008986.2

    Status: REVIEWED

    Source sequence(s)
    AK024744, AY091459, BC041089, CA449326, DA103416, DA353439
    Consensus CDS
    CCDS7354.1
    UniProtKB/Swiss-Prot
    O14802
    Related
    ENSP00000361446.3, ENST00000372371.8
    Conserved Domains (3) summary
    cd02736
    Location:10211360
    RNAP_III_Rpc1_C; Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain
    cd02583
    Location:24891
    RNAP_III_RPC1_N; Largest subunit (RPC1) of eukaryotic RNA polymerase III (RNAP III), N-terminal domain
    cl25425
    Location:8411058
    RNAP_largest_subunit_C; Largest subunit of RNA polymerase (RNAP), C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    77975149..78029515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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