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CD160 CD160 molecule [ Homo sapiens (human) ]

Gene ID: 11126, updated on 7-Jun-2020

Summary

Official Symbol
CD160provided by HGNC
Official Full Name
CD160 moleculeprovided by HGNC
Primary source
HGNC:HGNC:17013
See related
Ensembl:ENSG00000117281 MIM:604463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NK1; BY55; NK28
Summary
CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]
Expression
Biased expression in spleen (RPKM 5.2), duodenum (RPKM 1.7) and 12 other tissues See more
Orthologs

Genomic context

See CD160 in Genome Data Viewer
Location:
1q21.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (145719312..145739288)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145695798..145715639, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NBPF member 25, pseudogene Neighboring gene G protein-coupled receptor 89A Neighboring gene PDZ domain containing 1 Neighboring gene ring finger protein 115 Neighboring gene RNA polymerase III subunit C Neighboring gene nudix hydrolase 17 Neighboring gene protein inhibitor of activated STAT 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46513

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MHC class I protein complex binding IEA
Inferred from Electronic Annotation
more info
 
MHC class I receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
MHC class Ib receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
activating MHC class I receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
T cell costimulation IDA
Inferred from Direct Assay
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
mucosal immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of CD4-positive, alpha-beta T cell costimulation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of adaptive immune memory response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-gamma secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of natural killer cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of natural killer cell mediated immune response to tumor cell IEA
Inferred from Electronic Annotation
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
anchored component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anchored component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CD160 antigen
Names
CD160 transmembrane isoform
CD160-delta Ig
natural killer cell receptor BY55
natural killer cell receptor, immunoglobulin superfamily member

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007053.4NP_008984.1  CD160 antigen precursor

    See identical proteins and their annotated locations for NP_008984.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AA463248, AC242845, BC014465, CD638675
    Consensus CDS
    CCDS72861.1
    UniProtKB/Swiss-Prot
    O95971
    UniProtKB/TrEMBL
    Q6FH89
    Related
    ENSP00000358294.1, ENST00000369288.7

RNA

  1. NR_103845.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA463248, AC242845, BC014465, CD638675

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    145719312..145739288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509104.2XP_011507406.1  CD160 antigen isoform X1

    See identical proteins and their annotated locations for XP_011507406.1

    UniProtKB/TrEMBL
    B8PRF2
  2. XM_005272929.3XP_005272986.1  CD160 antigen isoform X1

    See identical proteins and their annotated locations for XP_005272986.1

    UniProtKB/TrEMBL
    B8PRF2
    Related
    ENSP00000385199.4, ENST00000401557.7
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