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LOC111157042 epidermal growth factor receptor [ Enhydra lutris kenyoni (northern sea otter) ]

Gene ID: 111157042, updated on 11-Apr-2024

Summary

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Gene symbol
LOC111157042
Gene description
epidermal growth factor receptor
See related
EnsemblRapid:ENSELKG00000008190
Gene type
protein coding
RefSeq status
MODEL
Organism
Enhydra lutris kenyoni (sub-species: kenyoni)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae; Lutrinae; Enhydra
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
28
Annotation release Status Assembly Chr Location
100 current ASM228890v2 (GCF_002288905.1) Unplaced Scaffold NW_019154135.1 (5459332..5657340, complement)

NW_019154135.1Genomic Context describing neighboring genes Neighboring gene VOPP1 WW domain binding protein Neighboring gene LanC like glutathione S-transferase 2 Neighboring gene 60S ribosomal protein L30-like Neighboring gene SEC61 translocon subunit gamma

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_019154135 Unplaced Scaffold Reference ASM228890v2 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Enhydra lutris kenyoni Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM228890v2 Primary Assembly

Genomic

  1. NW_019154135.1 Reference ASM228890v2 Primary Assembly

    Range
    5459332..5657340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022518253.1 → XP_022373961.1  epidermal growth factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A2Y9KK28
    Related
    ENSELKP00000010779.1, ENSELKT00000012038.1
    Conserved Domains (5) summary
    cd12093
    Location:581 → 624
    TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
    cd05108
    Location:651 → 963
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    pfam00757
    Location:132 → 282
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:4 → 115
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:452 → 583
    GF_recep_IV; Growth factor receptor domain IV

  2. XM_022518254.1 → XP_022373962.1  epidermal growth factor receptor isoform X2

    UniProtKB/TrEMBL
    A0A2Y9KJA9
    Related
    ENSELKP00000010800.1, ENSELKT00000012062.1
    Conserved Domains (5) summary
    cd12093
    Location:536 → 579
    TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
    cd05108
    Location:606 → 918
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    pfam00757
    Location:90 → 237
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:263 → 383
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:407 → 538
    GF_recep_IV; Growth factor receptor domain IV
Nucleotide Protein
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