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PRDM7 PR/SET domain 7 [ Homo sapiens (human) ]

Gene ID: 11105, updated on 10-Dec-2019

Summary

Official Symbol
PRDM7provided by HGNC
Official Full Name
PR/SET domain 7provided by HGNC
Primary source
HGNC:HGNC:9351
See related
Ensembl:ENSG00000126856 MIM:609759
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PFM4; ZNF910
Summary
This gene encodes a member of a family of proteins that may have roles in transcription and other nuclear processes. The encoded protein contains a KRAB (Kruppel-associated box) domain -A box and a SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain and may function as a histone methyltransferase. [provided by RefSeq, Aug 2013]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See PRDM7 in Genome Data Viewer
Location:
16q24.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (90056566..90077339, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (90122974..90143708, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene growth arrest specific 8 Neighboring gene GAS8 antisense RNA 1 Neighboring gene urate (hydroxyiso-) hydrolase, pseudogene Neighboring gene uncharacterized LOC105376786 Neighboring gene tubulin beta 8 class VIII pseudogene 7 Neighboring gene family with sequence similarity 157 member C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of PR domain containing 7 (PRDM7) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129525

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone methyltransferase activity (H3-K4 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
histone H3-K4 methylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable histone-lysine N-methyltransferase PRDM7
Names
PR domain 7
PR domain containing 7
PR domain zinc finger protein 7
PR-domain family protein 4
NP_001091643.1
XP_005256331.1
XP_011521131.1
XP_011521133.1
XP_016878371.1
XP_016878372.1
XP_016878373.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098173.1NP_001091643.1  probable histone-lysine N-methyltransferase PRDM7

    See identical proteins and their annotated locations for NP_001091643.1

    Status: REVIEWED

    Source sequence(s)
    AC133919, AF274348, AM690991
    Consensus CDS
    CCDS45557.1
    UniProtKB/Swiss-Prot
    Q9NQW5
    Related
    ENSP00000496449.1, ENST00000643008.1
    Conserved Domains (4) summary
    smart00317
    Location:246364
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00349
    Location:2785
    KRAB; krueppel associated box
    pfam01352
    Location:2764
    KRAB; KRAB box
    pfam09514
    Location:171201
    SSXRD; SSXRD motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    90056566..90077339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522829.1XP_011521131.1  probable histone-lysine N-methyltransferase PRDM7 isoform X3

    See identical proteins and their annotated locations for XP_011521131.1

    Conserved Domains (3) summary
    smart00349
    Location:2785
    KRAB; krueppel associated box
    pfam01352
    Location:2764
    KRAB; KRAB box
    pfam09514
    Location:171201
    SSXRD; SSXRD motif
  2. XM_005256274.3XP_005256331.1  probable histone-lysine N-methyltransferase PRDM7 isoform X1

    See identical proteins and their annotated locations for XP_005256331.1

    UniProtKB/Swiss-Prot
    Q9NQW5
    Related
    ENSP00000396732.2, ENST00000449207.7
    Conserved Domains (4) summary
    smart00317
    Location:246364
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00349
    Location:2785
    KRAB; krueppel associated box
    pfam01352
    Location:2764
    KRAB; KRAB box
    pfam09514
    Location:171201
    SSXRD; SSXRD motif
  3. XM_017022883.1XP_016878372.1  probable histone-lysine N-methyltransferase PRDM7 isoform X2

  4. XM_017022882.1XP_016878371.1  probable histone-lysine N-methyltransferase PRDM7 isoform X2

  5. XM_017022884.1XP_016878373.1  probable histone-lysine N-methyltransferase PRDM7 isoform X4

  6. XM_011522831.3XP_011521133.1  probable histone-lysine N-methyltransferase PRDM7 isoform X5

    Related
    ENSP00000455390.1, ENST00000568473.5
    Conserved Domains (2) summary
    smart00349
    Location:2785
    KRAB; krueppel associated box
    pfam01352
    Location:2764
    KRAB; KRAB box

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_052996.2: Suppressed sequence

    Description
    NM_052996.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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