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KRR1 KRR1 small subunit processome component homolog [ Homo sapiens (human) ]

Gene ID: 11103, updated on 8-Nov-2020

Summary

Official Symbol
KRR1provided by HGNC
Official Full Name
KRR1 small subunit processome component homologprovided by HGNC
Primary source
HGNC:HGNC:5176
See related
Ensembl:ENSG00000111615 MIM:612817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRB2; RIP-1
Expression
Ubiquitous expression in appendix (RPKM 20.3), bone marrow (RPKM 19.6) and 25 other tissues See more
Orthologs

Genomic context

See KRR1 in Genome Data Viewer
Location:
12q21.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (75490863..75511609, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (75891419..75905418, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcyphosine 2 Neighboring gene GLIPR1 like 1 Neighboring gene GLIPR1 like 2 Neighboring gene uncharacterized LOC105369844 Neighboring gene GLI pathogenesis related 1 Neighboring gene uncharacterized LOC107984533 Neighboring gene phosphogluconate dehydrogenase pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify HIV-1 Rev binding protein 2 (KRR1; RIP-1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify HIV-1 Rev binding protein 2 (KRR1; RIP-1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify HIV-1 Rev binding protein 2 (KRR1; RIP-1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify HIV-1 Rev binding protein 2 (KRR1; RIP-1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev Information on HIV-1 rev binding protein 2 is the result of a direct sequence submission to NCBI. Interaction with HIV-1 Rev is assumed based on the name of the protein, however no publications describing this interaction have been identified PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human small subunit (SSU) processome component, homolog (KRR1) at amino acid residues 286-287 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
rRNA processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
KRR1 small subunit processome component homolog
Names
HIV-1 Rev-binding protein 2
HIV-1 rev binding protein 2
KRR-R motif-containing protein 1
KRR1, small subunit (SSU) processome component, homolog
Rev interacting protein
rev-interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007043.7NP_008974.5  KRR1 small subunit processome component homolog

    See identical proteins and their annotated locations for NP_008974.5

    Status: VALIDATED

    Source sequence(s)
    AC121761, BC005225
    Consensus CDS
    CCDS9012.1
    UniProtKB/Swiss-Prot
    Q13601
    Related
    ENSP00000229214.4, ENST00000229214.9
    Conserved Domains (2) summary
    smart00322
    Location:158208
    KH; K homology RNA-binding domain
    COG1094
    Location:56230
    Krr1; rRNA processing protein Krr1/Pno1, contains KH domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    75490863..75511609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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