KRR1 KRR1 small subunit processome component [ Homo sapiens (human) ]

Gene ID: 11103, updated on 5-Aug-2026

Summary

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Official Symbol: KRR1provided by HGNC
Official Full Name: KRR1 small subunit processome componentprovided by HGNC
Primary source: HGNC:HGNC:5176
See related: Ensembl:ENSG00000111615 MIM:612817; AllianceGenome:HGNC:5176
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HRB2; RIP-1
Summary: Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Located in chromosome; intercellular bridge; and nuclear lumen. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in appendix (RPKM 20.3), bone marrow (RPKM 19.6) and 25 other tissues See more
Orthologs: all
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Genomic context

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See KRR1 in Genome Data Viewer

Location:: 12q21.2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (75490863..75511609, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (75465553..75486296, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (75884643..75905389, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The antibody response to KRR1 was higher in sera of patients with invasive ductal carcinoma than in sera of patients with other histological types of breast tumors.
Title: Autoantibody Response to ZRF1 and KRR1 SEREX Antigens in Patients with Breast Tumors of Different Histological Types and Grades.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify HIV-1 Rev binding protein 2 (KRR1; RIP-1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify HIV-1 Rev binding protein 2 (KRR1; RIP-1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify HIV-1 Rev binding protein 2 (KRR1; RIP-1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify HIV-1 Rev binding protein 2 (KRR1; RIP-1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Rev	rev	Information on HIV-1 rev binding protein 2 is the result of a direct sequence submission to NCBI. Interaction with HIV-1 Rev is assumed based on the name of the protein, however no publications describing this interaction have been identified	PubMed
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human small subunit (SSU) processome component, homolog (KRR1) at amino acid residues 286-287 by the HIV-1 protease	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-H56474 (e-PCR)
- UniSTS:29485

RH47132 (e-PCR)
- UniSTS:4654

STS-N32834 (e-PCR)
- UniSTS:23087

D12S1480E (e-PCR)
- UniSTS:153934

RH18004 (e-PCR)
- UniSTS:70991

RH149 (e-PCR)
- UniSTS:25945

SGC32697 (e-PCR)
- UniSTS:45678

RH46985 (e-PCR)
- UniSTS:67458

G64412 (e-PCR)
- UniSTS:163747

RH91538 (e-PCR)
- UniSTS:87216

G35331 (e-PCR)
- UniSTS:79550

KRR1 (e-PCR)
- UniSTS:506336

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA	NAS Non-traceable Author Statement more info	PubMed
involved_in ribosomal small subunit biogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	EXP Inferred from Experiment more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	EXP Inferred from Experiment more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	IDA Inferred from Direct Assay more info	PubMed
part_of small-subunit processome	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: KRR1 small subunit processome component homolog

Names: HIV-1 Rev-binding protein 2; HIV-1 rev binding protein 2; KRR-R motif-containing protein 1; KRR1, small subunit (SSU) processome component, homolog; Rev interacting protein; rev-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007043.7 → NP_008974.5 KRR1 small subunit processome component homolog

See identical proteins and their annotated locations for NP_008974.5

Status: VALIDATED

Source sequence(s)

AC121761, BC005225

Consensus CDS

CCDS9012.1

UniProtKB/Swiss-Prot

A0FIK6, A0JLP0, B2R989, E7EUQ0, Q13601, Q8NEA8, Q8TC37, Q96AT5

UniProtKB/TrEMBL

A0ACI8RQF1

Related

ENSP00000229214.4, ENST00000229214.9

Conserved Domains (2) summary

smart00322
Location:158 → 208

KH; K homology RNA-binding domain

COG1094
Location:56 → 230

Krr1; rRNA processing protein Krr1/Pno1, contains KH domain [Translation, ribosomal structure and biogenesis]