Format

Send to:

Choose Destination

HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 [ Homo sapiens (human) ]

Gene ID: 11100, updated on 9-Aug-2020

Summary

Official Symbol
HNRNPUL1provided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein U like 1provided by HGNC
Primary source
HGNC:HGNC:17011
See related
Ensembl:ENSG00000105323 MIM:605800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E1BAP5; E1B-AP5; HNRPUL1
Summary
This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in testis (RPKM 41.5), ovary (RPKM 40.7) and 25 other tissues See more
Orthologs

Genomic context

See HNRNPUL1 in Genome Data Viewer
Location:
19q13.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41262519..41307787)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41768391..41813811)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily S member 1 Neighboring gene AXL receptor tyrosine kinase Neighboring gene tRNA-Lys (anticodon TTT) 10-1 Neighboring gene RNA, 7SL, cytoplasmic 34, pseudogene Neighboring gene uncharacterized LOC105372401 Neighboring gene coiled-coil domain containing 97 Neighboring gene transforming growth factor beta 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that HNRNPUL1 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with HNRNPUL1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12944

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA processing TAS
Traceable Author Statement
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
response to virus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein U-like protein 1
Names
E1B 55kDa associated protein 5
E1B-55 kDa-associated protein 5
adenovirus early region 1B-associated protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301016.3NP_001287945.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform e

    See identical proteins and their annotated locations for NP_001287945.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform e, which has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC011462, AC011510
    Consensus CDS
    CCDS82351.1
    UniProtKB/TrEMBL
    B7Z4B8
    Related
    ENSP00000263367.3, ENST00000263367.7
    Conserved Domains (3) summary
    pfam13671
    Location:334479
    AAA_33; AAA domain
    cd12884
    Location:122299
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:334472
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  2. NM_001321208.2NP_001308137.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC011462, AC011510
    Consensus CDS
    CCDS12577.1
    UniProtKB/Swiss-Prot
    Q9BUJ2
    UniProtKB/TrEMBL
    A0A024R0J9
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  3. NM_001321211.2NP_001308140.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC011462, AC011510
    Consensus CDS
    CCDS12577.1
    UniProtKB/Swiss-Prot
    Q9BUJ2
    UniProtKB/TrEMBL
    A0A024R0J9, A8K3W4
    Related
    ENSP00000472629.1, ENST00000593587.5
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  4. NM_007040.6NP_008971.2  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_008971.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC011462, AC011510
    Consensus CDS
    CCDS12576.1
    UniProtKB/Swiss-Prot
    Q9BUJ2
    Related
    ENSP00000375863.2, ENST00000392006.8
    Conserved Domains (4) summary
    smart00513
    Location:337
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam13671
    Location:423568
    AAA_33; AAA domain
    cd12884
    Location:211388
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:423561
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  5. NM_144732.5NP_653333.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform d

    See identical proteins and their annotated locations for NP_653333.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding region compared to variant 1, resulting in an isoform (d) that maintains the reading frame but is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC011462, AC011510
    Consensus CDS
    CCDS12577.1
    UniProtKB/Swiss-Prot
    Q9BUJ2
    UniProtKB/TrEMBL
    A0A024R0J9
    Related
    ENSP00000473132.1, ENST00000595018.5
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    41262519..41307787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258464.4XP_005258521.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_005258521.1

    UniProtKB/TrEMBL
    A0A0A0MRA5
    Related
    ENSP00000340857.3, ENST00000352456.7
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  2. XM_011526393.3XP_011524695.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011524695.1

    UniProtKB/TrEMBL
    A0A0A0MRA5
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  3. XM_011526395.3XP_011524697.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011524697.1

    UniProtKB/TrEMBL
    A0A0A0MRA5
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  4. XM_011526392.3XP_011524694.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X2

    Related
    ENSP00000470687.1, ENST00000602130.5
    Conserved Domains (4) summary
    smart00513
    Location:337
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam13671
    Location:423568
    AAA_33; AAA domain
    cd12884
    Location:211388
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:423561
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  5. XM_005258459.4XP_005258516.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1

    Related
    ENSP00000367460.3, ENST00000378215.8
    Conserved Domains (4) summary
    smart00513
    Location:337
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam13671
    Location:423568
    AAA_33; AAA domain
    cd12884
    Location:211388
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:423561
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  6. XM_005258463.4XP_005258520.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_005258520.1

    UniProtKB/TrEMBL
    A0A0A0MRA5
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  7. XM_011526394.3XP_011524696.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011524696.1

    UniProtKB/TrEMBL
    A0A0A0MRA5
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  8. XM_005258465.5XP_005258522.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_005258522.1

    UniProtKB/TrEMBL
    A0A0A0MRA5
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  9. XM_005258461.5XP_005258518.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X3

    Conserved Domains (3) summary
    pfam13671
    Location:334479
    AAA_33; AAA domain
    cd12884
    Location:122299
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:334472
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144733.1: Suppressed sequence

    Description
    NM_144733.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_144734.1: Suppressed sequence

    Description
    NM_144734.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center