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PTPN21 protein tyrosine phosphatase non-receptor type 21 [ Homo sapiens (human) ]

Gene ID: 11099, updated on 5-Jan-2020

Summary

Official Symbol
PTPN21provided by HGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 21provided by HGNC
Primary source
HGNC:HGNC:9651
See related
Ensembl:ENSG00000070778 MIM:603271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPD1; PTPRL10
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 8.6), lung (RPKM 8.5) and 24 other tissues See more
Orthologs

Genomic context

See PTPN21 in Genome Data Viewer
Location:
14q31.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (88465778..88555007, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (88932122..89021123, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370613 Neighboring gene uncharacterized LOC105370612 Neighboring gene potassium two pore domain channel subfamily K member 10 Neighboring gene spermatogenesis associated 7 Neighboring gene uncharacterized LOC105370614 Neighboring gene RNA, U4 small nuclear 22, pseudogene Neighboring gene zinc finger CCCH-type containing 14 Neighboring gene EMAP like 5 Neighboring gene RNA, U4 small nuclear 92, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 21
Names
dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21)
protein-tyrosine phosphatase D1
NP_008970.2
XP_005267344.1
XP_006720074.1
XP_011534669.1
XP_011534670.1
XP_011534671.1
XP_016876427.1
XP_016876428.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046949.1 RefSeqGene

    Range
    4773..94002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007039.4NP_008970.2  tyrosine-protein phosphatase non-receptor type 21

    See identical proteins and their annotated locations for NP_008970.2

    Status: REVIEWED

    Source sequence(s)
    AL049834, AL162171, BM930068, DA860560, X79510
    Consensus CDS
    CCDS9884.1
    UniProtKB/Swiss-Prot
    Q16825
    Related
    ENSP00000452414.1, ENST00000556564.6
    Conserved Domains (6) summary
    smart00194
    Location:8961166
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:24222
    B41; Band 4.1 homologues
    cd00047
    Location:9231166
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:217307
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    pfam00373
    Location:109220
    FERM_M; FERM central domain
    pfam09379
    Location:2790
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    88465778..88555007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720011.3XP_006720074.1  tyrosine-protein phosphatase non-receptor type 21 isoform X2

    See identical proteins and their annotated locations for XP_006720074.1

    Conserved Domains (4) summary
    smart00194
    Location:7731043
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:8001043
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:94184
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    pfam00373
    Location:2797
    FERM_M; FERM central domain
  2. XM_017020938.2XP_016876427.1  tyrosine-protein phosphatase non-receptor type 21 isoform X2

    Conserved Domains (4) summary
    smart00194
    Location:7731043
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:8001043
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:94184
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    pfam00373
    Location:2797
    FERM_M; FERM central domain
  3. XM_005267287.3XP_005267344.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

    See identical proteins and their annotated locations for XP_005267344.1

    UniProtKB/Swiss-Prot
    Q16825
    Conserved Domains (6) summary
    smart00194
    Location:8961166
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:24222
    B41; Band 4.1 homologues
    cd00047
    Location:9231166
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:217307
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    pfam00373
    Location:109220
    FERM_M; FERM central domain
    pfam09379
    Location:2790
    FERM_N; FERM N-terminal domain
  4. XM_011536367.3XP_011534669.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

    See identical proteins and their annotated locations for XP_011534669.1

    UniProtKB/Swiss-Prot
    Q16825
    Conserved Domains (6) summary
    smart00194
    Location:8961166
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:24222
    B41; Band 4.1 homologues
    cd00047
    Location:9231166
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:217307
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    pfam00373
    Location:109220
    FERM_M; FERM central domain
    pfam09379
    Location:2790
    FERM_N; FERM N-terminal domain
  5. XM_011536369.2XP_011534671.1  tyrosine-protein phosphatase non-receptor type 21 isoform X3

    Conserved Domains (3) summary
    smart00194
    Location:692962
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:719962
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:13103
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
  6. XM_011536368.2XP_011534670.1  tyrosine-protein phosphatase non-receptor type 21 isoform X2

    See identical proteins and their annotated locations for XP_011534670.1

    Conserved Domains (4) summary
    smart00194
    Location:7731043
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:8001043
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:94184
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    pfam00373
    Location:2797
    FERM_M; FERM central domain
  7. XM_017020939.1XP_016876428.1  tyrosine-protein phosphatase non-receptor type 21 isoform X3

    Conserved Domains (3) summary
    smart00194
    Location:692962
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:719962
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:13103
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
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