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ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 [ Homo sapiens (human) ]

Gene ID: 11096, updated on 24-Dec-2019

Summary

Official Symbol
ADAMTS5provided by HGNC
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 5provided by HGNC
Primary source
HGNC:HGNC:221
See related
Ensembl:ENSG00000154736 MIM:605007
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11
Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]
Expression
Broad expression in ovary (RPKM 9.8), endometrium (RPKM 9.6) and 17 other tissues See more
Orthologs

Genomic context

See ADAMTS5 in Genome Data Viewer
Location:
21q21.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (26917922..26967758, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (28290231..28339439, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372760 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 1 Neighboring gene VISTA enhancer hs1684 Neighboring gene uncharacterized LOC112268279 Neighboring gene uncharacterized LOC112268280 Neighboring gene microRNA 4759 Neighboring gene glutathione peroxidase pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ADAM metallopeptidase with thrombospondin type 1 motif, 5 (ADAMTS5) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36738

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding TAS
Traceable Author Statement
more info
PubMed 
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix disassembly TAS
Traceable Author Statement
more info
 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
tooth eruption IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular matrix TAS
Traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 5
Names
a disintegrin and metalloproteinase with thrombospondin motifs 11
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
aggrecanase-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007038.5NP_008969.2  A disintegrin and metalloproteinase with thrombospondin motifs 5 preproprotein

    See identical proteins and their annotated locations for NP_008969.2

    Status: REVIEWED

    Source sequence(s)
    AF142099, AK094057, AP001600, AP001601, CA313018
    Consensus CDS
    CCDS13579.1
    UniProtKB/Swiss-Prot
    Q9UNA0
    Related
    ENSP00000284987.5, ENST00000284987.6
    Conserved Domains (4) summary
    smart00209
    Location:570622
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:269473
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:67168
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:732852
    ADAM_spacer1; ADAM-TS Spacer 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    26917922..26967758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452054.1XP_024307822.1  A disintegrin and metalloproteinase with thrombospondin motifs 5 isoform X2

    Conserved Domains (4) summary
    smart00209
    Location:514566
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:269413
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:67168
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:676796
    ADAM_spacer1; ADAM-TS Spacer 1
  2. XM_024452053.1XP_024307821.1  A disintegrin and metalloproteinase with thrombospondin motifs 5 isoform X1

    Conserved Domains (4) summary
    smart00209
    Location:570622
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:269473
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:67168
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:732852
    ADAM_spacer1; ADAM-TS Spacer 1
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