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Rpl10 ribosomal protein L10 [ Mus musculus (house mouse) ]

Gene ID: 110954, updated on 24-Jan-2023

Summary

Official Symbol
Rpl10provided by MGI
Official Full Name
ribosomal protein L10provided by MGI
Primary source
MGI:MGI:105943
See related
Ensembl:ENSMUSG00000008682 AllianceGenome:MGI:105943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
QM; QM16; D0HXS648; DXHXS648; DXHXS648E
Summary
Predicted to enable translation regulator activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in several processes, including embryonic brain development; regulation of cellular macromolecule biosynthetic process; and ribosomal large subunit assembly. Predicted to act upstream of or within translation. Located in cytoplasm. Is active in synapse. Colocalizes with smooth endoplasmic reticulum. Is expressed in several structures, including limb; nervous system; otocyst; skin; and surface ectoderm. Human ortholog(s) of this gene implicated in autistic disorder and syndromic X-linked mental retardation 35. Orthologous to human RPL10 (ribosomal protein L10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 662.4), genital fat pad adult (RPKM 624.3) and 27 other tissues See more
Orthologs
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Genomic context

See Rpl10 in Genome Data Viewer
Location:
X A7.3; X 37.94 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73314422..73316741)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74270816..74273135)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene filamin, alpha Neighboring gene emerin Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene deoxyribonuclease 1-like 1 Neighboring gene small nucleolar RNA, H/ACA box 70 Neighboring gene microRNA 7091 Neighboring gene predicted gene 14846

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC107630

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
 
enables translation regulator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in embryonic brain development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within translation ISO
Inferred from Sequence Orthology
more info
 
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
PubMed 
colocalizes_with smooth endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L10
Names
24.6 kDa protein
24.6kDa protein
protein QM homolog
ribosomal protein 10
NP_443067.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052835.4NP_443067.1  60S ribosomal protein L10

    See identical proteins and their annotated locations for NP_443067.1

    Status: VALIDATED

    Source sequence(s)
    AL807376
    Consensus CDS
    CCDS41019.1
    UniProtKB/Swiss-Prot
    Q5M9K8, Q6ZWV3
    UniProtKB/TrEMBL
    A0A6P5P1X6, A2AM97
    Related
    ENSMUSP00000008826.8, ENSMUST00000008826.14
    Conserved Domains (1) summary
    PTZ00173
    Location:1209
    PTZ00173; 60S ribosomal protein L10; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    73314422..73316741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)