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Hspa13 heat shock protein 70 family, member 13 [ Mus musculus (house mouse) ]

Gene ID: 110920, updated on 12-May-2024

Summary

Official Symbol
Hspa13provided by MGI
Official Full Name
heat shock protein 70 family, member 13provided by MGI
Primary source
MGI:MGI:1309463
See related
Ensembl:ENSMUSG00000032932 AllianceGenome:MGI:1309463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Stch; 1600002I10Rik; B230217N24Rik
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Predicted to be involved in cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to be located in endoplasmic reticulum. Predicted to be active in mitochondrion. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Orthologous to human HSPA13 (heat shock protein family A (Hsp70) member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 10.3), CNS E18 (RPKM 6.6) and 23 other tissues See more
Orthologs
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Genomic context

See Hspa13 in Genome Data Viewer
Location:
16 C3.1; 16 43.36 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (75552078..75564575, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (75755190..75767276, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41474 Neighboring gene predicted gene, 30162 Neighboring gene predicted gene 15553 Neighboring gene STARR-positive B cell enhancer ABC_E1494 Neighboring gene STARR-positive B cell enhancer ABC_E8914 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene SAM domain, SH3 domain and nuclear localization signals, 1 Neighboring gene STARR-positive B cell enhancer ABC_E8643 Neighboring gene STARR-positive B cell enhancer ABC_E9430 Neighboring gene STARR-positive B cell enhancer mm9_chr16:75908045-75908345 Neighboring gene STARR-positive B cell enhancer mm9_chr16:75909418-75909719

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
heat shock 70 kDa protein 13
Names
heat shock protein 70kDa family, member 13
microsomal stress-70 protein ATPase core
stress 70 protein chaperone, microsome-associated, 60kD human homolog
stress 70 protein chaperone, microsome-associated, human homolog
stress-70 protein chaperone microsome-associated 60 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030201.3NP_084477.1  heat shock 70 kDa protein 13 precursor

    See identical proteins and their annotated locations for NP_084477.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    BC085181, BY133105, CO043820
    Consensus CDS
    CCDS28273.1
    UniProtKB/Swiss-Prot
    Q3TII6, Q8BM72, Q9D1X5
    Related
    ENSMUSP00000048817.9, ENSMUST00000046283.16
    Conserved Domains (2) summary
    cd10237
    Location:12463
    HSPA13-like_NBD; Nucleotide-binding domain of human HSPA13 and similar proteins
    PRK13930
    Location:32442
    PRK13930; rod shape-determining protein MreB; Provisional

RNA

  1. NR_027492.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK030553, BC085181, BY133105, CO043820

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    75552078..75564575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522849.4XP_006522912.1  heat shock 70 kDa protein 13 isoform X1

    See identical proteins and their annotated locations for XP_006522912.1

    UniProtKB/TrEMBL
    D3Z0Y0
    Related
    ENSMUSP00000109882.2, ENSMUST00000114244.2
    Conserved Domains (1) summary
    cl17037
    Location:12259
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily