U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chrna2 cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) [ Mus musculus (house mouse) ]

Gene ID: 110902, updated on 9-Mar-2023

Summary

Go to the top of the page Help
Official Symbol
Chrna2provided by MGI
Official Full Name
cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)provided by MGI
Primary source
MGI:MGI:87886
See related
Ensembl:ENSMUSG00000022041 AllianceGenome:MGI:87886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acra2; Acra-2
Summary
Predicted to enable acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity. Predicted to be involved in several processes, including cholinergic synaptic transmission; regulation of membrane potential; and response to nicotine. Located in cell periphery. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 4. Orthologous to human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 6.8), ovary adult (RPKM 1.4) and 6 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Chrna2 in Genome Data Viewer
Location:
14 D1; 14 34.36 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (66370685..66390397)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (66133236..66152948)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 2 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene epoxide hydrolase 2, cytoplasmic Neighboring gene PTK2 protein tyrosine kinase 2 beta Neighboring gene predicted gene, 52098 Neighboring gene predicted gene, 52099

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation. Jun H, et al. Dev Cell, 2020 Jul 6. PMID 32533922, Free PMC Article
  2. α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice. Lotfipour S, et al. Learn Mem, 2017 Jun. PMID 28507032, Free PMC Article
  3. Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors. Lotfipour S, et al. J Neurosci, 2013 May 1. PMID 23637165, Free PMC Article
  4. Nicotine gates long-term potentiation in the hippocampal CA1 region via the activation of alpha2* nicotinic ACh receptors. Nakauchi S, et al. Eur J Neurosci, 2007 May. PMID 17466021
  5. Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning. Mineur YS, et al. Genes Brain Behav, 2020 Jul. PMID 32447811, Free PMC Article

See all (34) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hippocampal knockdown of alpha2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning.
    Title: Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning.
  2. Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation.
    Title: Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation.
  3. These results reveal a beige-selective immune-adipose interaction mediated through CHRNA2 and identify a novel function of nicotinic acetylcholine receptors in energy metabolism.
    Title: An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling.
  4. The results of this study demonstrated that alpha2* nAChRs influenced hippocampus-dependent learning and memory, as well as nicotine-facilitated CA1 hippocampal synaptic plasticity.
    Title: α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice.
  5. Chrna2-expressing Martinotti cells selectively target L5 thick-tufted type A pyramidal cells (PCs) but not thin-tufted type B PCs.
    Title: Chrna2-Martinotti Cells Synchronize Layer 5 Type A Pyramidal Cells via Rebound Excitation.
  6. Study described Chrna2 expression in the amygdala and propose that this expression is a marker of the medial subpallium-derived amygdala
    Title: The α2-subunit of the nicotinic cholinergic receptor is specifically expressed in medial subpallium-derived cells of mammalian amygdala.
  7. These results demonstrate that nicotine withdrawal enhances neuronal activity within the interpeduncular nucleus and dorsal hippocampus, which is absent in mice null for alpha2-containing nAChRs.
    Title: α2-Null mutant mice have altered levels of neuronal activity in restricted midbrain and limbic brain regions during nicotine withdrawal as demonstrated by cfos expression.
  8. The results of this study suggested that loss of the mouse nAChR alpha2 subunit has very limited effects on baseline behavior but does lead to the potentiation of several nicotine-modulated behaviors.
    Title: Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC18795

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
  
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables quaternary ammonium group binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to nicotine ISO
Inferred from Sequence Orthology
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in membrane depolarization ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of inhibitory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in response to acetylcholine ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in neuron projection cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
neuronal acetylcholine receptor subunit alpha-2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144803.2 → NP_659052.1  neuronal acetylcholine receptor subunit alpha-2 precursor

    See identical proteins and their annotated locations for NP_659052.1

    Status: VALIDATED

    Source sequence(s)
    AC126272
    Consensus CDS
    CCDS27219.1
    UniProtKB/Swiss-Prot
    Q91X60
    Related
    ENSMUSP00000022620.10, ENSMUST00000022620.11
    Conserved Domains (2) summary
    TIGR00860
    Location:15 → 505
    LIC; Cation transporter family protein
    cd19015
    Location:36 → 242
    LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    66370685..66390397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518436.4 → XP_006518499.1  neuronal acetylcholine receptor subunit alpha-2 isoform X1

    See identical proteins and their annotated locations for XP_006518499.1

    UniProtKB/Swiss-Prot
    Q91X60
    Conserved Domains (2) summary
    TIGR00860
    Location:15 → 505
    LIC; Cation transporter family protein
    cd19015
    Location:36 → 242
    LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

  2. XM_006518435.3 → XP_006518498.1  neuronal acetylcholine receptor subunit alpha-2 isoform X1

    See identical proteins and their annotated locations for XP_006518498.1

    UniProtKB/Swiss-Prot
    Q91X60
    Conserved Domains (2) summary
    TIGR00860
    Location:15 → 505
    LIC; Cation transporter family protein
    cd19015
    Location:36 → 242
    LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)

  3. XM_006518434.3 → XP_006518497.1  neuronal acetylcholine receptor subunit alpha-2 isoform X1

    See identical proteins and their annotated locations for XP_006518497.1

    UniProtKB/Swiss-Prot
    Q91X60
    Related
    ENSMUSP00000145896.2, ENSMUST00000206455.2
    Conserved Domains (2) summary
    TIGR00860
    Location:15 → 505
    LIC; Cation transporter family protein
    cd19015
    Location:36 → 242
    LGIC_ECD_nAChR_A2; extracellular domain of nicotinic acetylcholine receptor subunit alpha 2 (CHRNA2)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91X60.1 GenPept UniProtKB/Swiss-Prot:Q91X60

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous