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Kcnq3 potassium voltage-gated channel, subfamily Q, member 3 [ Mus musculus (house mouse) ]

Gene ID: 110862, updated on 25-Jan-2022

Summary

Official Symbol
Kcnq3provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily Q, member 3provided by MGI
Primary source
MGI:MGI:1336181
See related
Ensembl:ENSMUSG00000056258 AllianceGenome:MGI:1336181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables calmodulin binding activity; potassium channel activity; and voltage-gated ion channel activity. Acts upstream of or within membrane hyperpolarization and potassium ion transmembrane transport. Located in cell surface; main axon; and plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including central nervous system; midgut; retina; and rib. Used to study benign neonatal seizures. Human ortholog(s) of this gene implicated in autistic disorder and benign neonatal seizures. Orthologous to human KCNQ3 (potassium voltage-gated channel subfamily Q member 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in cortex adult (RPKM 8.4), frontal lobe adult (RPKM 5.4) and 5 other tissues See more
Orthologs
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Genomic context

See Kcnq3 in Genome Data Viewer
Location:
15 D1; 15 29.16 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (65858223..66158485, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (65986374..66286636, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (65826477..66117786, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene otoconin 90 Neighboring gene C protein (AA 1-159) Neighboring gene HERV-H LTR-associating 1 Neighboring gene predicted gene 27242 Neighboring gene predicted gene, 30929 Neighboring gene predicted gene, 41340 Neighboring gene ribosome production factor 2 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated ion channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to ammonium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within membrane hyperpolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in axon initial segment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon initial segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon initial segment ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in node of Ranvier IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated potassium channel complex IGI
Inferred from Genetic Interaction
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily KQT member 3
Names
KQT-like 3
potassium channel subunit alpha KvLQT3
voltage-gated potassium channel subunit Kv7.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152923.3NP_690887.2  potassium voltage-gated channel subfamily KQT member 3

    See identical proteins and their annotated locations for NP_690887.2

    Status: VALIDATED

    Source sequence(s)
    AC091276, AC102633, AC110897
    Consensus CDS
    CCDS49619.1
    UniProtKB/Swiss-Prot
    Q8K3F6
    Related
    ENSMUSP00000063380.7, ENSMUST00000070256.9
    Conserved Domains (4) summary
    pfam00520
    Location:140364
    Ion_trans; Ion transport protein
    pfam03520
    Location:453657
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:270354
    Ion_trans_2; Ion channel
    pfam11956
    Location:781867
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    65858223..66158485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159073.1XP_036014966.1  potassium voltage-gated channel subfamily KQT member 3 isoform X1

    Conserved Domains (2) summary
    pfam03520
    Location:36235
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam11956
    Location:355451
    KCNQC3-Ank-G_bd; Ankyrin-G binding motif of KCNQ2-3

RNA

  1. XR_875218.3 RNA Sequence

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