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ADAM29 ADAM metallopeptidase domain 29 [ Homo sapiens (human) ]

Gene ID: 11086, updated on 17-Jun-2019

Summary

Official Symbol
ADAM29provided by HGNC
Official Full Name
ADAM metallopeptidase domain 29provided by HGNC
Primary source
HGNC:HGNC:207
See related
Ensembl:ENSG00000168594 MIM:604778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT73; svph1
Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is highly expressed in testis and may be involved in human spermatogenesis. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 20.8) See more
Orthologs

Genomic context

See ADAM29 in Genome Data Viewer
Location:
4q34.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (174918358..174978180)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (175839509..175899331)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene glycine receptor alpha 3 Neighboring gene uncharacterized LOC101928551 Neighboring gene uncharacterized LOC105377552 Neighboring gene disintegrin and metalloproteinase domain-containing protein 21-like Neighboring gene PC4 and SFRS1 interacting protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 29
Names
a disintegrin and metalloproteinase domain 29
cancer/testis antigen 73
epididymis secretory sperm binding protein
metallaproteinase-disintegrin (ADAM29)
testis secretory sperm-binding protein Li 207a

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130703.1NP_001124175.1  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

    See identical proteins and their annotated locations for NP_001124175.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
    Source sequence(s)
    AK292410, BC036070, DB051105, DB073142
    Consensus CDS
    CCDS3823.1
    UniProtKB/Swiss-Prot
    Q9UKF5
    UniProtKB/TrEMBL
    A0A140VJD8
    Related
    ENSP00000414544.1, ENST00000445694.5
    Conserved Domains (5) summary
    smart00608
    Location:483618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:198386
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:406478
    Disintegrin; Disintegrin
    pfam01562
    Location:32150
    Pep_M12B_propep; Reprolysin family propeptide
    cl25764
    Location:725819
    PAT1; Topoisomerase II-associated protein PAT1
  2. NM_001130704.1NP_001124176.1  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

    See identical proteins and their annotated locations for NP_001124176.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
    Source sequence(s)
    AK292410, BC036070, DB073142, DB080702
    Consensus CDS
    CCDS3823.1
    UniProtKB/Swiss-Prot
    Q9UKF5
    UniProtKB/TrEMBL
    A0A140VJD8
    Related
    ENSP00000384229.3, ENST00000404450.8
    Conserved Domains (5) summary
    smart00608
    Location:483618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:198386
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:406478
    Disintegrin; Disintegrin
    pfam01562
    Location:32150
    Pep_M12B_propep; Reprolysin family propeptide
    cl25764
    Location:725819
    PAT1; Topoisomerase II-associated protein PAT1
  3. NM_001130705.1NP_001124177.1  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

    See identical proteins and their annotated locations for NP_001124177.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
    Source sequence(s)
    AK292410, BC036070, DB039551, DB073142
    Consensus CDS
    CCDS3823.1
    UniProtKB/Swiss-Prot
    Q9UKF5
    UniProtKB/TrEMBL
    A0A140VJD8
    Related
    ENSP00000423517.1, ENST00000514159.1
    Conserved Domains (5) summary
    smart00608
    Location:483618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:198386
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:406478
    Disintegrin; Disintegrin
    pfam01562
    Location:32150
    Pep_M12B_propep; Reprolysin family propeptide
    cl25764
    Location:725819
    PAT1; Topoisomerase II-associated protein PAT1
  4. NM_001278125.1NP_001265054.1  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

    See identical proteins and their annotated locations for NP_001265054.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
    Source sequence(s)
    AC105914, AK292410, BC036070, DB078627
    Consensus CDS
    CCDS3823.1
    UniProtKB/Swiss-Prot
    Q9UKF5
    UniProtKB/TrEMBL
    A0A140VJD8
    Related
    ENSP00000484862.1, ENST00000615367.4
    Conserved Domains (5) summary
    smart00608
    Location:483618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:198386
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:406478
    Disintegrin; Disintegrin
    pfam01562
    Location:32150
    Pep_M12B_propep; Reprolysin family propeptide
    cl25764
    Location:725819
    PAT1; Topoisomerase II-associated protein PAT1
  5. NM_001278126.1NP_001265055.1  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

    See identical proteins and their annotated locations for NP_001265055.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
    Source sequence(s)
    AK292410, BC036070, DB051105, DB073142, DB078125
    Consensus CDS
    CCDS3823.1
    UniProtKB/Swiss-Prot
    Q9UKF5
    UniProtKB/TrEMBL
    A0A140VJD8
    Conserved Domains (5) summary
    smart00608
    Location:483618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:198386
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:406478
    Disintegrin; Disintegrin
    pfam01562
    Location:32150
    Pep_M12B_propep; Reprolysin family propeptide
    cl25764
    Location:725819
    PAT1; Topoisomerase II-associated protein PAT1
  6. NM_001278127.1NP_001265056.1  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

    See identical proteins and their annotated locations for NP_001265056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
    Source sequence(s)
    AK292410, BC036070, DB044176, DB073142
    Consensus CDS
    CCDS3823.1
    UniProtKB/Swiss-Prot
    Q9UKF5
    UniProtKB/TrEMBL
    A0A140VJD8
    Related
    ENSP00000478469.1, ENST00000618444.1
    Conserved Domains (5) summary
    smart00608
    Location:483618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:198386
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:406478
    Disintegrin; Disintegrin
    pfam01562
    Location:32150
    Pep_M12B_propep; Reprolysin family propeptide
    cl25764
    Location:725819
    PAT1; Topoisomerase II-associated protein PAT1
  7. NM_014269.4NP_055084.3  disintegrin and metalloproteinase domain-containing protein 29 preproprotein

    See identical proteins and their annotated locations for NP_055084.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 2, 3, 4, 5, 6, and 7 encode the same protein.
    Source sequence(s)
    AK292410, BC036070, DB073142, DB078034, DB080702
    Consensus CDS
    CCDS3823.1
    UniProtKB/Swiss-Prot
    Q9UKF5
    UniProtKB/TrEMBL
    A0A140VJD8
    Related
    ENSP00000352177.3, ENST00000359240.7
    Conserved Domains (5) summary
    smart00608
    Location:483618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:198386
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:406478
    Disintegrin; Disintegrin
    pfam01562
    Location:32150
    Pep_M12B_propep; Reprolysin family propeptide
    cl25764
    Location:725819
    PAT1; Topoisomerase II-associated protein PAT1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    174918358..174978180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531557.1XP_011529859.1  disintegrin and metalloproteinase domain-containing protein 29 isoform X1

    See identical proteins and their annotated locations for XP_011529859.1

    UniProtKB/Swiss-Prot
    Q9UKF5
    UniProtKB/TrEMBL
    A0A140VJD8
    Conserved Domains (5) summary
    smart00608
    Location:483618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:198386
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:406478
    Disintegrin; Disintegrin
    pfam01562
    Location:32150
    Pep_M12B_propep; Reprolysin family propeptide
    cl25764
    Location:725819
    PAT1; Topoisomerase II-associated protein PAT1
  2. XM_011531556.1XP_011529858.1  disintegrin and metalloproteinase domain-containing protein 29 isoform X1

    See identical proteins and their annotated locations for XP_011529858.1

    UniProtKB/Swiss-Prot
    Q9UKF5
    UniProtKB/TrEMBL
    A0A140VJD8
    Conserved Domains (5) summary
    smart00608
    Location:483618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:198386
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:406478
    Disintegrin; Disintegrin
    pfam01562
    Location:32150
    Pep_M12B_propep; Reprolysin family propeptide
    cl25764
    Location:725819
    PAT1; Topoisomerase II-associated protein PAT1
  3. XM_011531559.1XP_011529861.1  disintegrin and metalloproteinase domain-containing protein 29 isoform X1

    See identical proteins and their annotated locations for XP_011529861.1

    UniProtKB/Swiss-Prot
    Q9UKF5
    UniProtKB/TrEMBL
    A0A140VJD8
    Conserved Domains (5) summary
    smart00608
    Location:483618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:198386
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:406478
    Disintegrin; Disintegrin
    pfam01562
    Location:32150
    Pep_M12B_propep; Reprolysin family propeptide
    cl25764
    Location:725819
    PAT1; Topoisomerase II-associated protein PAT1
  4. XM_011531560.1XP_011529862.1  disintegrin and metalloproteinase domain-containing protein 29 isoform X1

    See identical proteins and their annotated locations for XP_011529862.1

    UniProtKB/Swiss-Prot
    Q9UKF5
    UniProtKB/TrEMBL
    A0A140VJD8
    Conserved Domains (5) summary
    smart00608
    Location:483618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:198386
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:406478
    Disintegrin; Disintegrin
    pfam01562
    Location:32150
    Pep_M12B_propep; Reprolysin family propeptide
    cl25764
    Location:725819
    PAT1; Topoisomerase II-associated protein PAT1
  5. XM_011531561.1XP_011529863.1  disintegrin and metalloproteinase domain-containing protein 29 isoform X1

    See identical proteins and their annotated locations for XP_011529863.1

    UniProtKB/Swiss-Prot
    Q9UKF5
    UniProtKB/TrEMBL
    A0A140VJD8
    Conserved Domains (5) summary
    smart00608
    Location:483618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:198386
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:406478
    Disintegrin; Disintegrin
    pfam01562
    Location:32150
    Pep_M12B_propep; Reprolysin family propeptide
    cl25764
    Location:725819
    PAT1; Topoisomerase II-associated protein PAT1
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