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Ptpa protein phosphatase 2 protein activator [ Mus musculus (house mouse) ]

Gene ID: 110854, updated on 26-Sep-2022

Summary

Official Symbol
Ptpaprovided by MGI
Official Full Name
protein phosphatase 2 protein activatorprovided by MGI
Primary source
MGI:MGI:1346006
See related
Ensembl:ENSMUSG00000039515 AllianceGenome:MGI:1346006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PR53; Ppp2r4; 2610042B21Rik
Summary
Predicted to enable several functions, including ATP binding activity; peptidyl-prolyl cis-trans isomerase activity; and protein homodimerization activity. Predicted to contribute to ATP hydrolysis activity. Predicted to be involved in mitotic spindle organization; positive regulation of apoptotic process; and regulation of phosphoprotein phosphatase activity. Predicted to be located in nucleoplasm. Predicted to be part of calcium channel complex and protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Is expressed in embryo and forelimb bud. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 63.8), liver E14.5 (RPKM 52.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ptpa in Genome Data Viewer
Location:
2 B; 2 21.71 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30306062..30337819)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30416050..30447807)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene mitoguardin 2 Neighboring gene dolichyl pyrophosphate phosphatase 1 Neighboring gene carnitine acetyltransferase Neighboring gene predicted gene, 31291 Neighboring gene immediate early response 5-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC7129, MGC60706

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatase activator activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ATPase complex ISO
Inferred from Sequence Orthology
more info
 
part_of calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A activator
Names
phosphotyrosyl phosphatase activator
protein phosphatase 2A activator, regulatory subunit B
protein phosphatase 2A, regulatory subunit B (PR 53)
serine/threonine-protein phosphatase 2A regulatory subunit 4
serine/threonine-protein phosphatase 2A regulatory subunit B'
NP_001349662.1
NP_001349663.1
NP_620087.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362733.1NP_001349662.1  serine/threonine-protein phosphatase 2A activator isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL954299
    Conserved Domains (1) summary
    pfam03095
    Location:26319
    PTPA; Phosphotyrosyl phosphate activator (PTPA) protein
  2. NM_001362734.1NP_001349663.1  serine/threonine-protein phosphatase 2A activator isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL954299
    Conserved Domains (1) summary
    pfam03095
    Location:26229
    PTPA; Phosphotyrosyl phosphate activator (PTPA) protein
  3. NM_138748.5NP_620087.3  serine/threonine-protein phosphatase 2A activator isoform 2

    See identical proteins and their annotated locations for NP_620087.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK049184, AL954299
    Consensus CDS
    CCDS15883.1
    UniProtKB/Swiss-Prot
    P58389
    UniProtKB/TrEMBL
    Q543N6
    Related
    ENSMUSP00000046837.4, ENSMUST00000042055.10
    Conserved Domains (1) summary
    pfam03095
    Location:26316
    PTPA; Phosphotyrosyl phosphate activator (PTPA) protein

RNA

  1. NR_156126.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL954299
  2. NR_156127.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL954299, CX221557

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30306062..30337819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)